2
$\begingroup$

I wonder if it is possible to do the following reaction with its enantioselectivity:

Enantioselective synthesis of R-3-methyl-4-heptanone

I am trying to do it via enolate, but I don't know how to make only the R product or if it's even possible to distinguish between R or S simply using enolates.

There's another way?

Thanks!

$\endgroup$

1 Answer 1

3
$\begingroup$

Enders SAMP/RAMP hydrazone chemistry will do this(1).

The Wikipedia article on this technique is a good introduction:

enter image description here

(1): Corey, E. J.; Enders, D. (1976). "Applications of N,N-dimethylhydrazones to synthesis. Use in efficient, positionally and stereochemically selective C-C bond formation; oxidative hydrolysis to carbonyl compounds". Tetrahedron Letters. 17 (1): 3–6.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.

Not the answer you're looking for? Browse other questions tagged or ask your own question.