I wonder if it is possible to do the following reaction with its enantioselectivity:

Enantioselective synthesis of R-3-methyl-4-heptanone

I am trying to do it via enolate, but I don't know how to make only the R product or if it's even possible to distinguish between R or S simply using enolates.

There's another way?



1 Answer 1


Enders SAMP/RAMP hydrazone chemistry will do this(1).

The Wikipedia article on this technique is a good introduction:

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(1): Corey, E. J.; Enders, D. (1976). "Applications of N,N-dimethylhydrazones to synthesis. Use in efficient, positionally and stereochemically selective C-C bond formation; oxidative hydrolysis to carbonyl compounds". Tetrahedron Letters. 17 (1): 3–6.


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