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To anaesthetise the mucous membrane 2 separate drugs were given topically:

Oxybuprocaine hydrochloride and Lidocaine hydrochloride. The reason to use both of them seem to be beginning of action and its duration (the former starts faster but shorter, the latter starts later but longer acting).

If instead having them in separate bottles they will be mixed in one, would it cause any interactions between them?

oxybuprocaine:

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  • $\begingroup$ There likely wouldn't be a chemical reaction between them. Why would you want them in one bottle? $\endgroup$
    – jerepierre
    Commented Jun 12, 2015 at 14:38
  • $\begingroup$ @jerepierre It is more convenient and a part of actual (nondocumented) practice... I wanted to know does it affect the efficacy, thus I asked this question. $\endgroup$
    – Ilan
    Commented Jun 12, 2015 at 15:18

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Looking at the functionality, oxybuprocaine looks more likely to react with itself rather than lidocaine. As it's a salt and also no doubt from numerous medical trials, this doesn't occur, the anticipation would be that the two compounds would be fine. The $pK_a$'s of the tertiary amines would also be expected to be similar, so one shouldn't neutralise the other.

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  • $\begingroup$ Could you presume the reaction of oxybuprocaine with itself? $\endgroup$
    – Ilan
    Commented Jun 12, 2015 at 19:33
  • $\begingroup$ If it wasn't a salt, you could make the aniline cleave the ester given enough poke $\endgroup$
    – Beerhunter
    Commented Jun 12, 2015 at 20:44

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