12
$\begingroup$

I am trying to draw a polyisocyanopeptide with different kinds of monomeric units that intramolecularly interact with one another. However, I wanted to show these connections with its carbon backbone in the helix configuration.

An example of what I mean is shown below, taken from Kouwer et al (Nature 2013, 493 (7434), 651–655). How can I draw the alpha-helix as shown in red in ChemDraw (or any other program)?

Representation of the helical structure stabilized by the hydrogen-bond network between the peptide units

$\endgroup$
12
$\begingroup$

I use ChemDraw Professional 19.1.1.32. If you follow File>Open Templates>Advanced BioDraw, you will find the black helix that I have reoriented from horizontal to vertical. The red helix was enlarged and colored red. I hope this is of help.

| improve this answer | |
$\endgroup$
  • $\begingroup$ Alternative arrows: → (Markdown / HTML) and → / ► (Unicode) $\endgroup$ – Peter Mortensen Sep 11 at 20:11
11
$\begingroup$

This illustration may be a combination of two images, or simply a program I don't know about. However, there are many (3D) protein visualisation programs that can show alpha-helices such as PyMol, VMD or Yasara. Here you can ray-trace the image (i.e. transparent background) and then combine the illustration with something else, e.g. an illustration from ChemDraw to produce something like the illustration shown in the question.

If you don't have a protein to visualise in these programs, you can simply download one (with alpha helices) from the PDB database.

Example of a helix visualised in PyMol:

enter image description here

| improve this answer | |
$\endgroup$
7
$\begingroup$

This answer is for ChemDoodle, but I think you can import SVG files into ChemDraw as well.

Just take an SVG image of an alpha helix and copy and paste it into ChemDoodle. Or go to File -> Insert Image and select the SVG file from your computer. It doesn't have to be SVG, but they have advantages with scaling.

Made this using this File from Wikipedia, but if you have an SVG editor, you can make your own.

enter image description here

| improve this answer | |
$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.