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This tag should be applied to questions about mechanisms, selectivity, or other aspects of aldol reactions.

6 votes

Aldol of 7-oxooctanal

If in doubt, draw: Deprotonation at C-6 under thermodynamic control results in the more stable enolate (1c) and leaves the aldehyde (= the centre with the higher carbonyl activity) intact for the a …
Klaus-Dieter Warzecha's user avatar