This tag should be applied to questions about mechanisms, selectivity, or other aspects of aldol reactions.
The aldol reaction is a common method in organic synthesis of forming new carbon carbon bonds, via the reaction of an enolate (a carbon nucleophile) into a carbonyl group (a carbon electrophile).
The products of aldol reactions are β-hydroxyketones (though they may undergo elimination to form the unsaturated ketone under certain conditions), with up to two new stereo centres formed. This 1,3-oxygenation pattern is found throughout natural products, making aldol reactions a versatile reaction in total synthesis.
Applicability of the tag:
- All questions about the aldol reaction are necessarily about organic-chemistry and should be tagged as such.
- Depending on the nature of the question, additional tags such as reaction-mechanism or synthesis may also be appropriate.
Coverage of the aldol reaction can be found in any good organic chemistry textbook (see organic-chemistry for suggestions). For more in-depth coverage, the following books should be consulted:
- Mahrwald, R.; Modern Methods in Stereoselective Aldol Reactions; Wiley-VCH: Weinheim, 2013.