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Conversion of formamide to isonitril ( isocyanide)

Isocyanides are the only class of organic compounds which possess a divalent carbon. They react like a geminal nucleophilic/ electrophilicelectrophilic synthon with oxidation of the C(II) atom to C(IV), which parallels to the chemistry of carbenes and carbon monoxide.

Most commonly method for the synthesisSome of the most common methods for synthesizing isocyanides isinvolve the dehydration of formamideformamides. Various dehydrateddehydrating agents (Phosphenephosgene, POCl3phosphorus oxychloride) are used in the presence of a base (pyridine/TEA). In the follow reaction, however:

enter image description here$\hspace{2.4cm}$Reaction

I can't ableI'm unable to understand the role of p-TsCl, and also can't able to figurework out the reaction mechanism.

Conversion of formamide to isonitril ( isocyanide)

Isocyanides are the only class of organic compounds which possess a divalent carbon. They react like a geminal nucleophilic/ electrophilic synthon with oxidation of the C(II) atom to C(IV), which parallels to the chemistry of carbenes and carbon monoxide.

Most commonly method for the synthesis of isocyanides is dehydration of formamide. Various dehydrated agents (Phosphene, POCl3) are used in the presence of base (pyridine/TEA).

enter image description here

I can't able to understand the role of p-TsCl and also can't able to figure out the reaction mechanism.

Conversion of formamide to isocyanide

Isocyanides are the only class of organic compounds which possess a divalent carbon. They react like a geminal nucleophilic/electrophilic synthon with oxidation of the C(II) atom to C(IV), which parallels the chemistry of carbenes and carbon monoxide.

Some of the most common methods for synthesizing isocyanides involve the dehydration of formamides. Various dehydrating agents (phosgene, phosphorus oxychloride) are used in the presence of a base (pyridine/TEA). In the follow reaction, however:

$\hspace{2.4cm}$Reaction

I'm unable to understand the role of p-TsCl, and can't work out the reaction mechanism.

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Khan
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Conversion of formamide to isonitril ( isocyanide)

Isocyanides are the only class of organic compounds which possess a divalent carbon. They react like a geminal nucleophilic/ electrophilic synthon with oxidation of the C(II) atom to C(IV), which parallels to the chemistry of carbenes and carbon monoxide.

Most commonly method for the synthesis of isocyanides is dehydration of formamide. Various dehydrated agents (Phosphene, POCl3) are used in the presence of base (pyridine/TEA).

enter image description here

I can't able to understand the role of p-TsCl and also can't able to figure out the reaction mechanism.