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The branch of chemistry concerned with identifying and quantifying the chemical constituents of matter.
3
votes
1
answer
148
views
Make very accurate solutions without weighing
I am currently facing a hen-egg problem. For a LC-MS method development I need to prepare reference solutions which are used to calibrate the method. Since the method is to be used for quantification …
4
votes
1
answer
249
views
Stronger ESI signal for deuterated substances
I observe a constant phenomenon in my ESI measurements, which indicates that deuterated substances give a stronger signal than the same substance in non-deuterated form. Unfortunately I can't make any …
4
votes
0
answers
142
views
CuAAC "Click" reaction giving inconsistent results
I apologize in advance for the large amount of text and thank all those who take the time to read it.
The "Click" reaction after Fokin and Sharpless is known to achieve high yields without long rea …
5
votes
1
answer
130
views
Stubborn CuAAC reaction as derivatization for ESI-MS
Problem description
I have a substance that is extremely non-polar and therefore does not ionize in the ESI source, which makes it impossible to quantify small amounts. The substance contains only two …