Timeline for How does the branched structure of glycogen, increase its ability to be hydrolysed?
Current License: CC BY-SA 4.0
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| Feb 1, 2023 at 13:28 | comment | added | Growing6884 | So an endohydrolase would have more trouble hydrolysing glycogen for example, compared to an unbranched sugar polymer, because of the 1,6 glyosidic bonds, I would assume? | |
| Feb 1, 2023 at 13:23 | comment | added | Domen | Well, probably not. Imagine a large, very branched polymer. It is hard for an enzyme to access monomers that are located near the center of branching, because they are buried deeply in the branched structure. | |
| Feb 1, 2023 at 0:52 | comment | added | Growing6884 | Ok, then I would assume an endohydrolase would be able to hydrolyse branched and unbranched sugar polymers of the same size, at the same rate. | |
| Jan 31, 2023 at 14:12 | comment | added | Domen | Well, not all of them. Glycoside hydrolases can be classified as either endohydrolases or exohydrolases. | |
| Jan 31, 2023 at 2:31 | comment | added | Growing6884 | I guess this question comes from not learning that enzymes need 'free ends' to speed up glucose hydrolysis. | |
| Jan 30, 2023 at 15:28 | comment | added | Domen | To your first question regarding the branching: visualize (or draw) a linear polymer of glucose, and compare it with a highly branched polymer. The purpose of glycogen hydrolysis is to get glucose molecules. Imagine you have a lot of enzyme molecules. How many glucose molecules can be produced "at once" from a linear polymer, and how many from a branched one? In a linear polymer, you have only two ends, and only two molecules can be produced at once. However, in a branched polymer, you have a lot of "free ends" so many glucose molecules can be produced in the same time. | |
| Jan 30, 2023 at 13:45 | history | asked | Growing6884 | CC BY-SA 4.0 |