Timeline for Regarding Hard and Soft nucleophiles
Current License: CC BY-SA 4.0
3 events
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| Apr 30, 2021 at 22:42 | comment | added | orthocresol | For what it's worth, there's a good underlying question in here, i.e. why does HSAB theory fail in some cases. It's a shame that the example used, i.e. Me2Cd plus this 1,4-aromatic, is made up. If someone can find a real example, that would make this much better. (I strongly suspect that organocadmiums have been out of favour for... a while now.) | |
| Apr 30, 2021 at 22:28 | comment | added | orthocresol | HSAB theory is pretty dodgy. The "true" explanations for some of these things are usually rather more complicated, so people came up with this notion of "hard" and "soft" to explain some phenomena. The problem is that it's quite tautological: the HSAB concept only seems to make sense when applied precisely to these phenomena. Take it with a huge pinch of salt whenever you see it, and don't try to stretch it beyond the contexts that it's applied to. See e.g. onlinelibrary.wiley.com/doi/full/10.1002/anie.201007100 for a refutation of HSAB arguments. | |
| Apr 30, 2021 at 18:25 | history | asked | Satya | CC BY-SA 4.0 |