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andselisk
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Considering a wide variety of chromatographic columns used for (U)HPLC based on

  • phase type (normal or reverse);
  • column dimensions (geometry, length, inner diameter);
  • particle material $(\ce{SiO2},$ $\ce{ZrO2},$ $\ce{TiO2},\ldots),$ size, shape and porosity;
  • dopants/modifiers etc.,

as well as proprietary manufacturing techniques involved, is there a narrowed-down list of the bare-minimum column types that every analytical lab doing specifically liquid chromatography tandem mass spectrometry must have to cover the majority of the analytical routines (qualitative and quantitative analysis of short-chain fatty acids, primary metabolites, amino acids etc.)?

Background: a new LC-MS/MS lab is being created within a university's biochemistry division from the ground up both for the fundamental research and providing analytical services, so listing the most versatile and recent columns would be appreciated. I do realize the question is borderline off-topic being somewhat opinion-based, so it would be nice if the answer were based on a trustworthy source.

Considering a wide variety of chromatographic columns used for (U)HPLC based on

  • phase type (normal or reverse);
  • column dimensions (geometry, length, inner diameter);
  • particle material $(\ce{SiO2},$ $\ce{ZrO2},$ $\ce{TiO2},\ldots),$ size, shape and porosity;
  • dopants/modifiers etc.,

as well as proprietary manufacturing techniques involved, is there a narrowed-down list of the bare-minimum column types that every analytical lab doing specifically liquid chromatography tandem mass spectrometry must have to cover the majority of the analytical routines (qualitative and quantitative analysis of short-chain fatty acids, primary metabolites, amino acids etc.)?

Background: a new LC-MS/MS lab is being created within a biochemistry division from the ground up, so listing the most versatile and recent columns would be appreciated. I do realize the question is borderline off-topic being somewhat opinion-based, so it would be nice if the answer were based on a trustworthy source.

Considering a wide variety of chromatographic columns used for (U)HPLC based on

  • phase type (normal or reverse);
  • column dimensions (geometry, length, inner diameter);
  • particle material $(\ce{SiO2},$ $\ce{ZrO2},$ $\ce{TiO2},\ldots),$ size, shape and porosity;
  • dopants/modifiers etc.,

as well as proprietary manufacturing techniques involved, is there a narrowed-down list of the bare-minimum column types that every analytical lab doing specifically liquid chromatography tandem mass spectrometry must have to cover the majority of the analytical routines (qualitative and quantitative analysis of short-chain fatty acids, primary metabolites, amino acids etc.)?

Background: a new LC-MS/MS lab is being created within a university's biochemistry division from the ground up both for the fundamental research and providing analytical services, so listing the most versatile and recent columns would be appreciated. I do realize the question is borderline off-topic being somewhat opinion-based, so it would be nice if the answer were based on a trustworthy source.

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andselisk
  • 38.5k
  • 14
  • 133
  • 223

Considering a wide variety of chromatographic columns used for (U)HPLC based on

  • phase type (normal/reverse or reverse);
  • column dimensions (geometry/length/inner, length, inner diameter);
  • particle material $(\ce{SiO2},$ $\ce{ZrO2},$ $\ce{TiO2},\ldots),$ size, shape and porosity;
  • dopants/modifiers etc.,

as well as proprietary manufacturing techniques involved, is there a narrowed-down list of the bare-minimum column types that every analytical lab doing specifically liquid chromatography tandem mass spectrometry must have to cover the majority of the analytical routines (qualitative and quantitative analysis of short-chain fatty acids, primary metabolites, amino acids etc.)?

Background: a new LC-MS/MS lab is being created within a biochemistry division from the ground up, so listing the most versatile and recent columns would be appreciated. I do realize the question is borderline off-topic being somewhat opinion-based, so it would be nice if the answer were based on a trustworthy source.

Considering a wide variety of chromatographic columns used for (U)HPLC based on

  • phase type (normal/reverse);
  • column dimensions (geometry/length/inner diameter);
  • particle size, shape and porosity;
  • dopants/modifiers etc.,

as well as proprietary manufacturing techniques involved, is there a narrowed-down list of the column types that every analytical lab doing specifically liquid chromatography tandem mass spectrometry must have to cover the majority of the analytical routines (qualitative and quantitative analysis of short-chain fatty acids, primary metabolites, amino acids etc.)?

Background: a new LC-MS/MS lab is being created within a biochemistry division from the ground up, so listing the most versatile and recent columns would be appreciated. I do realize the question is borderline off-topic being somewhat opinion-based, so it would be nice if the answer were based on a trustworthy source.

Considering a wide variety of chromatographic columns used for (U)HPLC based on

  • phase type (normal or reverse);
  • column dimensions (geometry, length, inner diameter);
  • particle material $(\ce{SiO2},$ $\ce{ZrO2},$ $\ce{TiO2},\ldots),$ size, shape and porosity;
  • dopants/modifiers etc.,

as well as proprietary manufacturing techniques involved, is there a narrowed-down list of the bare-minimum column types that every analytical lab doing specifically liquid chromatography tandem mass spectrometry must have to cover the majority of the analytical routines (qualitative and quantitative analysis of short-chain fatty acids, primary metabolites, amino acids etc.)?

Background: a new LC-MS/MS lab is being created within a biochemistry division from the ground up, so listing the most versatile and recent columns would be appreciated. I do realize the question is borderline off-topic being somewhat opinion-based, so it would be nice if the answer were based on a trustworthy source.

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andselisk
  • 38.5k
  • 14
  • 133
  • 223

Is there a list of must-have columns for LC-MS/MS used in biochemistry/clinical lab setting?

Considering a wide variety of chromatographic columns used for (U)HPLC based on

  • phase type (normal/reverse);
  • column dimensions (geometry/length/inner diameter);
  • particle size, shape and porosity;
  • dopants/modifiers etc.,

as well as proprietary manufacturing techniques involved, is there a narrowed-down list of the column types that every analytical lab doing specifically liquid chromatography tandem mass spectrometry must have to cover the majority of the analytical routines (qualitative and quantitative analysis of short-chain fatty acids, primary metabolites, amino acids etc.)?

Background: a new LC-MS/MS lab is being created within a biochemistry division from the ground up, so listing the most versatile and recent columns would be appreciated. I do realize the question is borderline off-topic being somewhat opinion-based, so it would be nice if the answer were based on a trustworthy source.