S R Maiti
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Why do we get slightly more inversion product than retention product in SN1 reaction?
18 votes

As we know, $\ce{S_N1}$ reaction is stereochemically non specific. This means, that it does not force the formation of one stereoisomer, as $\ce{S_N2}$ does. In $\ce{S_N1}$ reaction, presence of ...

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Are pseudo-zeroth order reactions possible?
16 votes

I think to some extent, you can think about all zero-order reactions as "pseudo-zero-order" reactions. This is because it's not possible for a reaction to be true zero-order. How can it be ...

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Why doesn’t aniline undergo Friedel-Crafts alkylation?
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13 votes

The answer lies in the fact that aniline is a Lewis base and $\ce{AlCl3}$ is a Lewis acid. The reaction between aniline and $\ce{AlCl3}$ hampers the catalytic activity of $\ce{AlCl3}$ required to ...

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What is an example of chemical reaction that can be assisted by both an inorganic catalyst and an enzyme?
11 votes

There are many many examples of reactions that are usually done in biological systems with an enzyme, but can be done outside in the lab with general acid or base catalysis. Take for example the ...

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ORCA: How to plot an adiabatic potential in dihydrogen H2 molecule?
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10 votes

By adiabatic, I presume you mean the Born-Oppenheimer approximation (which is usually used). If you need a plot of potential against H-H distance, then you need to do a relaxed potential energy ...

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How to estimate the temperature needed to overcome an activation energy barrier?
8 votes

You could convert the rate constant($k$) to half-life($t_{1/2}$) which would give you an idea of the time scale required for the reaction to finish at a certain temperature. The equation to obtain ...

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Does rearrangement take place in the reaction between ethenylcyclohexane and iodine chloride?
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8 votes

Yes, I believe the rearrangement can happen. However, the product from the rearrangement is probably not the major one. The closest reaction to what you have drawn that I could find on SciFinder is ...

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Why is the endo product the major product in a Diels-Alder reaction?
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8 votes

What is the endo-selectivity of Diels-Alder reactions? If the diene used in the Diels-Alder reaction has asymmetric substituents at the end carbons, and if the dienophile is unsymmetric, then two ...

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ELSD detection principle
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8 votes

ELSD is an acronym for Evaporative Light Scattering Detector. It is used as a quasi-universal detector for HPLC. The first step is the nebulization of the column effluents with a dry gas as you have ...

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How do steric effects affect inductive effect in compounds with tetravalent nitrogen?
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6 votes

Since you are asking for a theoretical explanation, I believe a theoretical calculation might be helpful. It is possible to calculate the partial charges on atoms using electronic structure programs. ...

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Meta-directing nature of anilinium cations
6 votes

This does not answer your question exactly, but I hope this can shed some light on the anomalous behaviour of anilinium cations. First of all, it is not true that the para-product is always favoured ...

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Aspirin Hydrolysis at pH 2
6 votes

To understand the pH rate profile of the Aspirin hydrolysis, we have to look at all the possible mechanisms through which the hydrolysis may take place. A good rule of thumb for interpreting a pH rate ...

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Can substituted acetone undergo Cannizzaro reaction?
6 votes

As Greg E. wrote in his answer, Cannizzaro reaction does not usually occur with ketones. However there are some instances where ketones give Cannizzarro products. From the Wikipedia page of Cannizarro ...

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Newman projection of 3-methylpentane
6 votes

The Newman projections of 3-methylpentane are: This is a staggered conformation. Another one would be This is also a stggered conformation and is the most stable of conformers. You can generate ...

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What is the general formula for tertiary alcohol?
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5 votes

A tertiary ($\mathrm{3^\circ}$) alcohol is compound in which the hydroxy group ($\ce{-OH}$) is attached to a tertiary carbon; which again indicates a saturated carbon that is attached to three carbons....

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Finding the rate of a reaction given experimental data for reaction kinetics
5 votes

As I said in the comments, your image is quite low resolution. But, if I read it correctly, you have got the exponents in the rate law wrong. Solving this type of problem is simple, you just need to ...

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What makes selectivity other than activation energy?
5 votes

It's not just the activation energy that determines the selectivity of a reaction. There is a thermodynamic factor too. This is the classic kinetic-vs-thermodynamic control that you will find in most ...

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Maximum Local Value for the Electron Density
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5 votes

Short Answer: There is a limit to the maximum value of electron density $\rho_e(\vec{r})$. Long Answer: It is true that electrons repel each other, so as the electron density increases, the ...

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Reimer–Tiemann-like reaction of catechol with diiodomethane
5 votes

Catechol does react with diiodomathane in presence of $\ce{NaOH}$ as the base. But it does not perform Reimer-Tiemann reaction, but instead it forms methylenedioxybenzene (2H-1,3-Benzodioxole is the ...

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What is the alternative to chromyl chloride test?
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5 votes

Why chromyl chloride test is used as confirmatory test for $\ce{Cl-}$: According to this Wikipedia page: The chromyl chloride test entails heating a sample suspected of containing chloride with ...

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Why does copper form bubbles in vinegar in this situation?
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5 votes

When you put a zinc rod in a acid solution containing $\ce{H^+}$ ions, the zinc piece loses $\ce{Zn^{2+}}$ ions to the solution leaving electrons behind. These electrons attract hydrogen atoms to the ...

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Why hydrogen bonding in some acids make them a stronger acid when it is present even before deprotonation?
4 votes

The other answer has given the major conformer of the protonated form of the o-hydroxybenzoic acid, but I believe there is a part of your question that still remains to be answered. You asked why the ...

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Why does ester hydrolysis occur in basic medium
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4 votes

In basic medium, there is a huge amount of $\ce{OH-}$ and they will deprotonate the carboxylic acid as soon as it forms. $$\ce{RCOOR' + OH- <=> RCOOH + R'O-}$$ $$\ce{R'O- + H2O <=> R'OH + ...

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Can endergonic reactions be driven by heat?
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4 votes

I think you can look at this entirely from the perspective of entropy (forget about the Gibbs free energy for a moment). You can divide the universe into two parts, the system and its surroundings. ...

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Comparing the zero point vibrational energies of DCl and HCl
4 votes

I don't know which equations you are using, but this is the one I was taught: $$E(v)=hc\tilde{\nu}\left( v+\frac{1}{2}\right) -hc\tilde{\nu}\chi\left(v+\frac{1}{2}\right)^2.\tag{1}$$ Here, $\tilde{\nu}...

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Gaussian calculation - PCM model for IRC compared to gas phase?
4 votes

Option 2 is the most scientific and rigorous. You should re-run the IRC in solvent again because the reaction path can be different from what you got in the gas phase. Now, will it be different in ...

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What is the mechanism for thermal decarboxylation of a generic carboxylic acid (not special cases like beta-ketocarboxylic acid or malonic acids)?
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4 votes

The decarboxylation of any carboxylic acid can basically take place in four ways: Unimolecular free radical mechanism (homolytic fission) However, in case of thermal decomposition there has ...

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Elimination of OH from spirocyclic compounds
4 votes

This question has been unanswered for quite long, and meanwhile, I have found an answer, so I wanted to share it. On treating the compound with sulfuric acid, the $\ce{OH}$ groups will be protonated ...

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The ways to determine if an ionic compound is paramagnetic or not
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3 votes

As mentioned by @IvanNeretin and @IanBush in the comments, the cation in this case can be neglected as they have noble gas configuration, and therefore are diamagnetic. In general, for an ionic solid, ...

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Lother Mayer curve
3 votes

It is an interesting question, and I am not completely sure on everything I write below. First of all, atomic volume is defined as the "quotient obtained by dividing the atomic weight of an ...

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