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I'm assuming the OP concerns chemical means of modifying residues. Multiple protein residues other than Lysine may be labeled with an adduct. Here are some examples: Histidine residues may be labeled using an epoxide attached to a ligand. (Chen et al., 2003) Cysteine residues may be labeled with a nitrile derivative where the sulhydryl acts as the ...


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Background Topiramate (TPM) is an anticonvulsive and antimigraine drug that helps prevent or reduce the frequency of epileptic seizures and that is used as a prophylaxis of migraine. (Shank and Maryanoff, 2008) TPM not only inhibits kainate subtypes and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) subtypes of glutamate activated ionotrophic ...


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