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As a matter, of fact, yes, uncharged phosphoryl thiocholines do seem to interact with acetylcholinesterase differently compared to their charged analogs. For example, it has been reported that Sundwall (1961) reported that P2S was considerably more effective as an antagonist of the lethal action of 37 SN +(isopropoxy-2-trimethylammonio-tiomethylphosphino ...

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