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1 vote

What can I do if I don't get a phase separation between my organic and water phases?

An additional option besides adding salt and having patience, is to place your funnel inside a heating oven at a temperature that is not harmful to your reaction. In my experience, it helped with the ...
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4 votes
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How to synthesize 1,1,1-trichloro-2,4-dimethylpentan-2-ol from methyl isobutyl ketone?

Chloroform anion generated with powdered KOH reacts with ketones to give addition resulting in the trichloromethyl methyl carbinol as reported by Willgerodt in 1881 (Chem. Berichte vol 14 245-60) as ...
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5 votes
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How does coenzyme A produce proton from pyruvate ions?

The reversible conversion of pyruvate ion and coenzyme A (CoA) into $\ce{acetyl-CoA}$ and formate ion (Figure 1) is not a one step reaction but a complex multistep radical reaction (Ref.1), thus it is ...
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1 vote

Information about liquefied carbon factories from carbon dioxide

If you compress a gas in a syringe at $20°$C, its temperature increases a bit (say $+ 10$ °C). If you now maintain the pressure and let the compressed gas cool down, its temperature goes slowly back ...
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-1 votes

Information about liquefied carbon factories from carbon dioxide

I think you mean dry ice; solid carbon dioxide, not carbon. It is made very cold and freezes. At atmospheric pressure carbon dioxide sublimes, no liquid; gas to solid. Look up a CO2 phase diagram. Not ...
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8 votes

The major product of radical halogenation: Why is it a halogen attached to a primary carbon and not a tertiary carbon in the given example?

The experimental relative rates of chlorination to primary, secondary, and tertiary positions are $1$, $3.8$, and $5$, respectively. In the given compound $\ce{(CH3)3CH}$, there are $9$ identical ...
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1 vote

Substitution v/s elimination

I think both elimination and substitution reaction will occur any of them can dominate cos ethoxide ion is a strong nucleophile and in presence of a alcohol as a solvent. So the reaction which will ...
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4 votes
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Reaction of 2-carboxybenzaldehyde with $\ce{NaCN/HCl}$ - does carboxylic acid interfere?

@Waylander's suggestion that 3-cyanophthalide [3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile] 6 is expected as the product of the reaction is well-reasoned. This reaction has been reported by Hesse, ...
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9 votes
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Converting benzaldehyde to benzophenone in no more than two steps

I could give you a satisfactory answer, but I don't say that this is the best method. Conversion of benzaldehyde to benzoyl chloride:You can achieve this by adding $\ce{Cl2}$ or $\ce{SO2Cl2}$ (or ...
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1 vote

Reactivity of 1-bromo-4-tert-butylcyclohexane isomers with methanol

You are right on the part of E2, 2 will react slower. The reactivity of SN1 follows the same order - the carbocations are same but in 1 due to $\ce{Br}$ being on the axial position, the $\ce{C-Br}$ ...
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1 vote

Temperature required for E1 elimination reaction

This is a question that is answered by careful experimentation [Possibly the experiment has been done already]. Primary and secondary require high T to dehydrate usually about 150-200C, intermediate ...
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Stable conformer of protonated ethane-1,2-diamine

I'm not 100% convinced that both amines will protonate at the same time, since protonation of a charged molecule is different than the neutral. At the moment, I don't have the time to calculate the $\...
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2 votes

Can I synthesize 4-aminophenol and/or acetic anhydride at home?

Commenters already provided the main points to your question. So, I am providing some more info. to make it into an answer. @TheRelentlessNucleophile already provided the prepchem article for ...
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Is hydrolysis of acid chlorides still favored when the resulting acids cannot donate their protons?

The data more or less explain why acid chlorides are made by reaction of acids with PCl5, SOCl2 and similar compounds rather than anhydrous HCl. In water or similar solvents [see Schotten-Baumann ...
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-1 votes

Reactivity of 1-bromo-4-tert-butylcyclohexane isomers with methanol

These are geometric isomers, cis-trans compounds so the RS nomenclature is not appropriate. If they were mirror images they would have identical reaction rates in an achiral system The general idea is ...
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1 vote
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Reaction of 1,3 diphenyl propane with alkaline potassium permanganate followed by acidification

I think you are going to get two equivalents of benzoic acid from oxidation of both benzylic sites based on the summary here. The mechanism of this oxidative process is AFAIK not completely understood....
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Why are radicals considered electron deficient?

From high school chemistry, almost 30 years ago, the basic explanation that we were given (not overly scientific) is as follows. Each atom "wants" to have a full outer electron shell. For ...
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4 votes

Why are radicals considered electron deficient?

Radicals should not always be perceived as "electron-deficient". They are not defined in this way. You should always keep the classification criteria in mind. What makes a radical electron &...
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4 votes

How much Calcium Hydroxide to manufacture calcium formate?

One of the interesting observations I have noted in neutralizations with calcium hydroxide on a large scale is that the reaction of a not-very strong acid (like organic acids) with Ca(OH)2 is quite ...
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2 votes

How does molecular structure contribute in the property of fluorescence?

The fluorescence yield is $\varphi =k_k/(k_f+k_n)$ where $k_f$ is the rate constant for fluorescence and $k_n$ that for non-radiative processes. If $k_n \gg k_f$ then the fluorescence yield dis very ...
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0 votes

Systematic and preferred names of acetamide

The first thing to do when constructing a systematic name is to find the parent structure - be it a cycle, or in this case an acyclic chain. You choose the parent structure with the most skeletal ...
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6 votes
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Is RCOOH + H2SO4 + heat a viable alternative to RCOCl + AlCl3 in Friedel-Crafts acylation?

Sure it is possible. It is best known for intramolecular cyclisation using Polyphosphoric Acid (PPA) or Methanesulfonic acid more here. Examples are known of intermolecular Friedel-Craft acylation ...
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3 votes
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How does Calanolide A react with NaOH solution?

Coumarins are hydrolysed by hydroxide as described in this paper Coumaric acid contains a phenol and a carboxylic acid group and can consume 2 eqs of hydroxide, though hydrolysis can occur with only 1 ...
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