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9 votes

Acidity of metronidazole

There are no acidic groups in metronidazole. The $\mathrm{p}K_\mathrm{a}$ you are quoting relates to the protonated form of the molecule (usually hydrochloride or benzoate). The most easily removed ...
Waylander's user avatar
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6 votes

Acidity of metronidazole

As Waylander correctly predict that presence of no acidic groups in metronidazole framework. The reported $\mathrm{p}K_\mathrm{a}$ value is related to the protonated hydrophilic form of the molecule (...
Mathew Mahindaratne's user avatar
5 votes
Accepted

Mechanism of ring expansion of epoxide

BF3 facilitates the nucleophilic opening of epoxides by binding to the oxygen. Under its influence the lithium anion of ethoxyacetylene adds at the least hindered sites to both the epoxides opening ...
Waylander's user avatar
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5 votes

Is the 4H-Pyran Cation aromatic?

As noted by Nicolau in the comments, this is really the pyrylium ion. It is usually drawn with a double bond to the oxygen atom, which then formally takes the positive charge. This allows an extra pi ...
Oscar Lanzi's user avatar
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4 votes
Accepted

How is nitrogen the most powerful electron donor in aromatic rings?

Nitrogen is able to donate its electrons to the aromatic pi-system more readily than oxygen and sulfur because its p-orbital (which contains the lone pair) is energetically closer to carbon (i.e., ...
Max Kallio's user avatar
1 vote

Understanding Hybridisation in Cyclic Compounds

The design of the question offers you four choices where choice 4 states nitrogen in both case 2 and 3 (formally) were $\text{sp}^2$ hybridized. Case 3 however differs from case 1 and 2 by that the ...
Buttonwood's user avatar
  • 30.2k

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