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Retrosynthesis of 4-ethyl-2,2,5,5-tetramethyl-1,3-dioxane

We can start the retrosynthesis by disconnecting the two $\ce{C-O}$ bonds of the acetal. This takes us to a diol that can be formed by reduction of a 1,3-dicarbonyl. A methyl group can be added by ...
GabrielAlx's user avatar
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Retrosynthesis of 4-ethyl-2,2,5,5-tetramethyl-1,3-dioxane

Start with the commercially available methyl 3-oxo-valerate, also called ethyl propionylacetate vendor here Dimethylate with potassium carbonate and MeI in refluxing acetonitrile or acetone. Reduce ...
Waylander's user avatar
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