New answers tagged drugs
0
I don't know of a "common" example but Reference (1) below outlines an example. From the abstract:
this report describes a novel chemical reaction between temazepam (a 3‐hydroxy‐1,4‐benzodiazepine) and ethanol under acidic conditions similar to those found in vivo, resulting in a 3‐ethoxylated product. Optimal conditions, kinetics, equilibrium, and the ...
3
A large percentage of pharmaceuticals are sold as salts, and sometimes even as co-crystals, i.e. a drug cation and a drug anion. You are right in the sense that the basic purpose is to make them soluble but this is not the only one. If it is a intravenous drug, salt form may have less pain. A low molecular weight medicine might be in a liquid form yet its ...
2
If we call the drug L, and the binding sites S, the equilibrium is the following:
$$\ce{LS <=> L + S}$$
The equilibrium constant expression is:
$$K_d = \frac{[\ce{L}] [\ce{S}]}{[\ce{LS}]}$$
With $[\ce{L}]_\mathrm{tot}$ as the total concentration of ligand and $[\ce{S}]_\mathrm{tot}$ the total concentration of binding sites, we can solve of $[\ce{L}]...
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