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4

Finally I find a primary reference by Oae et al.[1] They react benzenesulfonic acid with fused potassium hydroxide using isotopically labelled chemicals. The isotopic labelling results favor a direct nucleophilic substitution of hydroxide for sulfite, so that the only ring position involved in the reaction is that originally holding the sulfonate function. ...


2

There are many common antimicrobials in use, and one that might be comparatively easy to sythesize would be a quaternary ammonium compound. For example, this patent claims the "reaction is carried out in water." That said, the reactants and the resulting antibacterial might have intrinsic environmental and health hazards. BTW, why not investigate ...


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