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3

Given that the formula was a trade secret and that lithium was removed from the product ~70 years ago, the likelihood of this question being answered by providing a detailed formula seems remote. Note in addition that the formula might have evolved to reduce cost or improve market reception. You might therefore want to settle for an estimate of the upper ...


3

You may not necessarily need to start your procedure beginning with phenol. You may start it with readily available (for cheap price compared to the trouble you are going to have by handling methyl iodide, allyl bromide, and $\ce{AlBr3}$ or $\ce{AlCl3}$) 4-anisaldehyde (4-methoxybenzaldehyde). That is the exact product you are getting after your step 3. ...


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Normally, the efficacy of a drug is determined by the area under the curve of the entire time course of the drug in the body. The graphs here only show the initial rate of the change in pH but not the entire time course after the peak pH is reached. I assumed that these results were generated by an acid-base titration experiment in the laboratory and not ...


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If the extraction procedure does not involve HBr, then I would doubt it is the hydrobromide because: hydrobromide salts don't dissolve well in acetone; hydrobromide salts are rare in nature. According to the work by Bracci et al. [1], the major component of MeOH extraction of Brugmansia is atropine. Śramska et al. [2] used ethyl acetate extraction and ...


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Transdermal drug delivery is a complicated process governed not only by chemistry/physics, but also biology. Limiting ourselves to the physical/chemical aspects: Different solubility, both kinetic and thermodynamic Different tonicity - alters the osmotic pressure Different pH and buffering capacity of the formulation - altering charge state populations of ...


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Others have covered the practical parts a bit, so let's move on to the pharmacology of it. Dosage In a cup of coffee you can get ~120mg or more of caffeine. That quantity isn't really large so filling the whole room with caffeine droplets / powder could be practical. The body absorbs most of caffeine, whether given orally or by inhalation so it should be ...


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