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9 votes

Acidity of metronidazole

There are no acidic groups in metronidazole. The $\mathrm{p}K_\mathrm{a}$ you are quoting relates to the protonated form of the molecule (usually hydrochloride or benzoate). The most easily removed ...
Waylander's user avatar
  • 22.5k
5 votes

Can glycerol slow down the kinetics of an inhibitor going to a binding pocket of a target enzyme?

I am wondering if the glycerol, ca. 8 percent from my protein stock may slow down the kinetics that determine the binding of the inhibitor to the protein? When you change the solvent, a lot of things ...
Karsten's user avatar
  • 40.7k
5 votes

Acidity of metronidazole

As Waylander correctly predict that presence of no acidic groups in metronidazole framework. The reported $\mathrm{p}K_\mathrm{a}$ value is related to the protonated hydrophilic form of the molecule (...
Mathew Mahindaratne's user avatar
2 votes
Accepted

Why having a carbonyl group is not contributing to binding energy

"From my understanding, having a carbonyl group should increase the likelihood of interacting with amino acids, and thus contributing to binding." No. This is a fairly foundational ...
Erol Bakkalbasi's user avatar
2 votes

Can glycerol slow down the kinetics of an inhibitor going to a binding pocket of a target enzyme?

Reverse engineering the composition of your sample: here 8% is ambiguous, but assume it means the volume ratio of the original substances is 8:92. Glycerol has density ~1.261 g/cm3 ($\pu{20 ^\circ C}$)...
Buck Thorn's user avatar
  • 22.4k
1 vote

Anthracycline vs Angucycline

Angucyclines include every natural product consisting of an angular tetracyclic core, which is derived from a decaketide chain formed via the polyketide biosynthetic pathway, with hydrolyzable sugar ...
RaymartJay's user avatar
1 vote

Solubility of amlodipine besylate

According to OP, the monograph in the European Pharmacopoeia says: the drug amlodipine besylate is characterized as slightly soluble in water and freely soluble in methanol (additionally, sparingly ...
Mathew Mahindaratne's user avatar
1 vote

Medicinal chemistry: adding substituents to increase/decrease activity

Drug chemistry is complicated: simple patterns are not the norm For a drug to be effective it must meet many criteria, some simple and some very complex. Bioavailability, for example, depends on the ...
matt_black's user avatar
  • 36.8k
1 vote

LC-MS/MS analysis of rosuvastatin in rat plasma two peaks

Analysis of biomolecules chromatography can be a challenging exercise because these biomolecules can stick to any fluidic path of the chromatograph if they want to. Just to make sure, is every ...
AChem's user avatar
  • 41.1k

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