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If the substrate still binds to the protein, other parts of the mechanism are still in place. Specifically, the main chain amide groups that help to stabilize the tetrahedral intermediate are still present. In the absence of serine, water will attack the carbonyl. In the presence of serine and the absence of the histidine, serine will still be the ...


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Below is one way to write it that shows what the enzyme does and avoids the uncertainty of the details: $$\ce{E + H2O2 -> E-O + H2O}\tag{1}$$ $$\ce{E-O + H2O2 -> E-O2 + H2O}\tag{2}$$ $$\ce{E-O2 -> E + O2}\tag{3}$$ In words, the enzyme binds to the first molecule of hydrogen peroxide, release one molecule of water and holds on to the other oxygen ...


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