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It models an isobaric process: The titration is performed at constant pressure and temperature, meaning that a single ITC experiment offers data on the binding enthalpy, the equilibrium association constant and the stoichiometry, from which the entropy of binding and Gibbs energy can be computed. Hence, a single ITC experiment offers direct access to the ...


Yes, in my experience with a old GE-branded ITC-200 the cell is not sealed. The syringe for titration does cover a lot of the opening, but it is not sealing the cell from the atmosphere

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