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Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.

1
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Clearly, the approaches are going to be around enolate chemistry, but how to introduce the alkene? My starter for ten would be to start with a conjugated carbonyl. This is either acrolein, an acrylic …
answered Apr 1 '17 by Beerhunter
5
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I would hazard a guess that the economies of scale of where the process is located comes into play. Arkema may make bulk $\ce{H2O2}$ at industrial concentration so can just feed it in without transpor …
answered Jun 3 '15 by Beerhunter
8
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A key consideration for the Wolff-Kishner reduction is thermal stability of the substrate. High temperature is required for the classical reaction using hydrazine and KOH, sometimes up to 200 °C. This …
answered Aug 5 '15 by Beerhunter
3
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1) oxidise using your favourite method (pyridinium dichromate; metal catalyst and oxygen; hypochlorous acid etc.) to cyclopentanone. 2) Pd catalysis using a bidentate ligand e.g. DPPF, with a hindere …
answered Jun 8 '17 by Beerhunter
3
votes
Most amide coupling agents are suitable for esters. Feast your eyes on: Amide bond formation - beyond the myth of coupling reagents. This lists old favourites such as CDI, carbodiimides, etc. A lot o …
answered Aug 3 '15 by Beerhunter
2
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The methods required are generally outside of the mainstream lab chemistry, but that does not mean they can't be used in lab setups. As Waylander states, use of oxygen with acetic acid can be cataly …
answered Jun 16 by Beerhunter
1
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If you have the capability, convert the ketone to an enol ether and ozonolyse / oxidative cleave the alkene portion. You might want to cleave your acetate first, make your ether and then silylate , b …
answered Jun 6 '15 by Beerhunter
4
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When you mentioned column chromatography I had to assume you meant flash chromatography or biotage, which by implication is normal phase. When people mention HPLC they are normally defaulting to rever …
answered Oct 2 '17 by Beerhunter
2
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The synthesis proposed would not seem to offer much advantage as the question around selectivity is a matter of conjecture. There are two major industrial syntheses of paracetamol, mainly occurring …
answered Jun 25 '16 by Beerhunter