Questions tagged [total-synthesis]

Questions involving the synthesis of a natural product or complex drug/molecule pertaining to the individual steps involved or the overall scheme of the reaction (ex. question regarding the individual steps of Woodward's synthesis of vitamin B12).

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Substituted Diene Preparation from Aniline / Novel Cyclic Imine Preparation

I have recently been studying the following mechanism recommended by another user from the following DOI: https://doi.org/10.1016/j.tet.2004.06.026. In this paper, the following mechanism is proposed (...
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Fischer Esterification of the Unsaturated 3-Butenoic Acid with Methyl Alcohol

I am attempting to perform a Fisher esterification of 3-butenoic acid (vinyl acetic acid). I believe that this should theoretically work and not disturb the unsaturated region of the molecule, but I'm ...