Questions tagged [total-synthesis]

Questions involving the synthesis of a natural product or complex drug/molecule pertaining to the individual steps involved or the overall scheme of the reaction (ex. question regarding the individual steps of Woodward's synthesis of vitamin B12).

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L-lysine acetate synthesis

Is it possible to synthesize L-lysine acetate in the following steps? First, mix L-lysine HCl with an excess of NaOH and just enough water so that the total water in the product is enough to solve all ...
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Chemoselectively dihydroxylate a terminal alkene in the presence of an internal alkene?

The goal is to dihydroxylate the exo alkene, and then convert to a ketone. Any suggestions would be apprecitated to either chemoselectively convert the terminal alkene, or directly convert the ...
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Substituted Diene Preparation from Aniline / Novel Cyclic Imine Preparation

I have recently been studying the following mechanism recommended by another user from the following DOI: https://doi.org/10.1016/j.tet.2004.06.026. In this paper, the following mechanism is proposed (...
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Fischer Esterification of the Unsaturated 3-Butenoic Acid with Methyl Alcohol

I am attempting to perform a Fisher esterification of 3-butenoic acid (vinyl acetic acid). I believe that this should theoretically work and not disturb the unsaturated region of the molecule, but I'm ...