Questions tagged [synthesis]

Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.

134 questions with no upvoted or accepted answers
Filter by
Sorted by
Tagged with
0
votes
0answers
45 views

Synthesis question: Using reductive amination to form pyrrolidine

What molecule results from treating 4-oxopentanal with $\ce{NH4Cl}$ and $\ce{NaCNBH3}$? Why? Is this a good, high yield reaction? I believe that pyrrolidine is formed because amination will convert ...
0
votes
0answers
35 views

Enamine Formation in a Diketone

I am trying to form an enamine, and I was trying to figure out if the following reaction is possible: Would this reaction terminate after the formation of the shown product, or will the other ...
0
votes
0answers
39 views

Why bridged bicyclic compound isn't a preferred product over fused bicylic compound in Robinson Annulation reaction?

Why a doubly-fused cyclohexanone is formed instead of bridged cyclohexanone like product which would be more flexible (entropically-favoured)? Also, the OH group not being at the bridgehead carbon ...
0
votes
0answers
28 views

Trying to synthesize and crystallize iron (iii) ammonium sulfate

I've been following instructions (from here, the first method) to synthesize iron (iii) ammonium sulfate and crystallize it. The first attempt was a fail, I spilled most of my solution and what I ...
0
votes
0answers
73 views

Is it possible to synthesize a benzene ring with every carbon on the ring substituted?

We recently began covering aromatic electrophillic substitution in my first year organic chemistry course, and we've been discussing the nature of certain functional groups being activating $(\ce{-OH},...
0
votes
0answers
26 views

Easy way to derivatize silsesquioxanes

I have a polymer end-capped with a Polysilsesquioxane (POSS) like this one: where R=i-butyl. I haven't found much info on what type or reactions these POSS groups can undergo. I would like to know ...
0
votes
0answers
26 views

Selective halogenation of an alkane

Is it possible to selectively halogenate a certain position on an alkane chain, and also get a good yield? I understand that to form such haloalkanes, taking a different substrate other than alkane (...
0
votes
0answers
41 views

Laboratory preparation of catechol

The wikipedia page says that catechol is prepared from phenol and hydrogen peroxide. As this is a very simple proces, compared to the OrgSyn procedure from salicylaldehyde, I would prefer it. Does ...
0
votes
0answers
24 views

What is a good substitue for monoethanolamine in creating conductive silver nanoparticles?

In this paper (https://pubs.rsc.org/en/content/articlepdf/2017/ra/c7ra05125e) and a few others, chemists create PAA-coated silver nanoparticles in a colloidal conductive ink. (Mods - I cant seem to ...
0
votes
0answers
88 views

What's the purpose of an ice bath when preparing a nitration mix from KNO3?

Most preparations for nitrocellulose from $\ce{(KNO3 + H2SO4)}$ mixture require the use of an ice bath during the process of dissolving $\ce{KNO3}$ into $\ce{H2SO4}$. Last time I did this I omitted ...
0
votes
0answers
148 views

Preparation of compounds using acetoacetic ester synthesis

I've been given the following exercise in organic chemistry, and I'm at a complete loss. The text book doesn't cover the subject at all. I have some knowledge of melonic ester synthesis. As an ...
0
votes
0answers
30 views

method of separating product and conserving the catalyst

I'm looking for a way to separate reaction product of iodobenzene with ethyl 2-methyl-3-oxopentanoate in 1,4-dioxane (toluene is an alternative as a solvent). The catalyst being used is Pd2(dba)3 with ...
0
votes
0answers
53 views

Hydroxy Protecting Groups that are not Cleaved Under Acidic Conditions

I am currently designing a synthesis requiring the use of hydroxy protecting groups. The problem I am having is that the protecting group must be able to survive highly acidic conditions. I would have ...
0
votes
0answers
159 views

Balanced equation for Schweizer's reagent production?

In Thompson's Illustrated Guide to Home Chemistry Experiments the chemical formula for Schweizer's reagent is represented as $\ce{[Cu(NH3)4](OH)2}$ (although Wikipedia represents it as $\ce{[Cu(NH3)4(...
0
votes
0answers
114 views

Preparation of 3-ethylpentan-3-ol

Is it possible to use CI3TMS (a carbon with three iodo groups and a trimethylsilyl protecting group) and three equivalents of an ethyl grignard reagent to prepare 3-ethylpentan-3-ol? By deprotecting ...
0
votes
0answers
73 views

Is it possible to synthesize permanganate electrochemically?

I have been researching the production of peroxy acids and other strong oxidizers. I was wondering if it's possible to produce permanganic acid if I were to cast an anode containing Manganese Dioxide ...
0
votes
0answers
78 views

Products of the oxidation of 1,4-dimethylcyclohexane

I am having difficulty identifying the second product. Is it an ether, or a kind of epoxide? I am out of ideas on how to reach it. However, I do have a general idea how to receive the first product, ...
0
votes
0answers
63 views

Aldol Reaction in Water Not Working

I am conducting an Aldol formation reaction in water, and below is the experimental protocol I am following (from J. Org. Chem. 1994, 59, 3590—3596): Formation of Aldol in Water using Yb(OTf)3 ...
0
votes
0answers
163 views

A broad singlet at 2.27 ppm?

I took the $\mathrm{^{1}H}$-NMR (CDCl3 solvent) of my product, 2,2-dimethoxy acetic acid. Below is what I see: $\delta \: \pu{4.862 ppm}$ (1H), $\delta \: \pu{3.521 ppm}$ (6.78H), $\delta \: \pu{2....
0
votes
0answers
55 views

What's the purpose of stirring the mixture at 0 degree and dding NaOH to the organic reaction mixture?

I used to follow the lab protocol without thinking, but I now hope to understand why certain procedures are done. I am synthesizing dimethoxyacetic acid from methyl dimethoxy acetate(so hydrolysis ...
0
votes
0answers
61 views

How to acetylate a thiol group in general?

I wonder (and have tried to find the answer by searching in synthetic chemistry resources) how do you acetylate thiol (R-SH) groups in general? For example the cysteine-SH group either alone to make S-...
0
votes
0answers
182 views

t-Boc protection of amide (urea)

I'm trying to prepare protected urea and I'd like to protect it with some alkali stable PG. Is it possible to protect urea with t-Boc? Or is there another way to get boc-protected urea?
0
votes
0answers
46 views

Monitoring amino acid esterification

I am trying to monitor the esterification of a non UV active amino acid.I used thionyl chloride and Methanol as reagents. As amino group is unprotected, Ninhydrin should give positive result for both ...
0
votes
0answers
809 views

Converting phenol to para-nitrophenol via nitrosophenol

Our class 12 text book says that if we treat phenol with mixture of concentrated $\ce HNO_3$ and $\ce H_2SO_4$, instead of nitration, the ring is oxidized to quinone. So, the book proposes that we ...
0
votes
0answers
4k views

P2NP synthesis ammonium acetate catalyst?

I am going to try to prepare some P2NP from benzaldehyde and nitroethane following this procedure: The aldehyde (5g), 5 ml. of the nitroalkane, and 2g of ammonium acetate were added to 20 ml of ...
0
votes
0answers
313 views

Simple Ethyl Acetate synthesis in absence of catalyst

To smoothen 3D printed PLA parts I need ethyl acetate. This is a pretty cheap solvent to synthesize but still to expensive to buy, so I would like to make it myself. I have seen that ethanol and ...
0
votes
0answers
341 views

Production of fluorine gas

I have to suggest a method in order to produce $\ce{F2}$. It also says that I should consult the redox potential values. I know that there is a way to produce fluoride which is: $$\ce{K2[MnF6] + 2 ...
0
votes
1answer
258 views

Why is moist hydrogen made to react with chlorine to give hydrogen chloride?

Moist hydrogen reacts with chlorine in diffused sunlight to give out hydrogen chloride. Why is moist hydrogen used? Why not dry hydrogen?
0
votes
1answer
10k views

Why is it necessary to heat an esterification reaction?

Why do we heat the mixture acid and alcohol? The reaction of esterification is exothermic so it is not affected by increasing temperature, then what is the use of heat ?
-1
votes
2answers
209 views

Phosphoryl bromide reaction with benzoic acid

I am trying to find out how $\ce{POBr3}$ reacts with $\ce{-COOH}$ group (benzoic acid to be specific). I found that it performs an elimination reaction with alcohols to give alkenes. I have also seen ...
-1
votes
2answers
464 views

How to make copper salicylate with electrolysis?

I am trying the following and it looks like it may be working, but I am not certain what the end product would be. Basic electrolysis setup: two cups distilled water, with 3 g of copper wire on anode,...
-2
votes
1answer
73 views

Synthesis of 3-(2-oxocyclohexyl)propanenitrile

Does this seem correct? The point is to draw the mechanisnm of which 3-(2-oxocyclohexyl)propanenitrile is synthesized from 1-(cyclohex-1-en-1-yl)pyrrolidine.
-4
votes
1answer
216 views

Preparation of potassium cyanide from potassium ferrocyanide via HCN

Does anyone have any experience with the preparation of potassium cyanide from potassium ferrocyanide via $\ce{HCN}$ method? I did some math and am going to proceed eventually, any advice would be ...
-6
votes
1answer
164 views

Why Silica and normal alumina can damage or destroy many metal complexes?

in case of organic ligand there r several techniques for purification,but in case of metal complex(Cr,Mn,Fe,Co) with schiff base , i have not seen any literature for the purification of them except ...

1 2
3