Questions tagged [synthesis]

Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.

Filter by
Sorted by
Tagged with
0
votes
1answer
386 views

questions about the synthesis of iodobenzene from aniline

I am conducting an experiment about synthesis of iodobenzene from aniline, referring to this site(and various sites) (http://www.prepchem.com/synthesis-of-iodobenzene/). Below is my experimental ...
-1
votes
1answer
97 views

Can you make imines from Formaldehyde or Acetaldehyde?

Title says it all. Wondering if imine formation would work with an aldehyde, even better would be formaldehyde.
3
votes
0answers
321 views

Reaction between Salicylaldehyde and 2-Benzoylpyridine

In a paper by Sheng et al (10.1016/j.dyepig.2018.07.036) the authors synthesize the compound MZC as shown in the scheme below. I'm looking for information about what the reaction mechanism is that ...
2
votes
1answer
459 views

Can thiols be created using a Grignard reagent?

I'm trying to find information on the synthesis of thiols via Grignard reagents. While looking at the synthesis routes on Wikipedia, it said that a Grignard reagent will react with sulphur to form ...
0
votes
0answers
861 views

Converting phenol to para-nitrophenol via nitrosophenol

Our class 12 text book says that if we treat phenol with mixture of concentrated $\ce HNO_3$ and $\ce H_2SO_4$, instead of nitration, the ring is oxidized to quinone. So, the book proposes that we ...
-2
votes
1answer
75 views

Synthesis of 3-(2-oxocyclohexyl)propanenitrile

Does this seem correct? The point is to draw the mechanisnm of which 3-(2-oxocyclohexyl)propanenitrile is synthesized from 1-(cyclohex-1-en-1-yl)pyrrolidine.
0
votes
1answer
60 views

Formation of (Gamma) Methylparaconic acid

I came across this question recently, I tried to devise a mechanism but I'm struck here, My try - Moreover, I think my mechanism is somewhat inefficient because of formation of some byproducts, ...
4
votes
1answer
448 views

Why is ethanol distilled off before adding water in the first step of a malonic synthesis?

I am doing a malonic synthesis shown below, and I wonder why I should distill ethanol off before adding water in the first step of the reaction (First I add absolute ethanol and solid sodium).
0
votes
1answer
408 views

How to predict ease of oxidation or reduction for a given oxidising or reducing agent? [closed]

I have never understood which agent will be able to oxidize or reduce which type of reactants and yield which type of products will be formed. For example I want to know about DIBAL-H and how is it ...
-1
votes
1answer
56 views

Predicting products of a reaction and balancing [closed]

2BiOCl + NaOH = BiOH + NaCl. This is the reaction where I am trying to get Bismuth Hydroxide as one product and salt. My problem is what is the state of Bismuth Hydroxide? Whether it is BiOH or Bi (OH)...
5
votes
2answers
665 views

Conversion of oxalic acid to malonic acid

The reagents I have used here are $\ce{LiAlH_4}$ which reduces the carboxylic groups into alcohol.Used $\ce{HIO_4}$ which breaks up the molecule into methanal. Then I applied Grignard reagent which ...
0
votes
1answer
2k views

Synthesis of 1-methylcyclopentene from cyclopentene

I have to put a methyl group on a cyclopentene. My teacher made this solution (the picture). But my first guess was just to use $\ce{CH3Cl}$ and $\ce{AlCl3}$. Why can't you do that?
4
votes
1answer
2k views

Ortho vs para alkylation of chlorobenzene

I have a question to the solution regarding the product formed in a reaction with chlorobenzene with the use of (i) $\ce{CH3CH2Cl}$ and (ii)$ \ce{AlCl3}$. Since the -Cl substituent is ortho- para-...
5
votes
2answers
346 views

Synthesis of branched alkanes

The question might seem kind of trivial, although it is even harder than I've thought. How can we synthesise branched alkanes from linear one? For example, I want to obtain 3,4,7,8-tetramethyldecane ...
0
votes
0answers
4k views

P2NP synthesis ammonium acetate catalyst?

I am going to try to prepare some P2NP from benzaldehyde and nitroethane following this procedure: The aldehyde (5g), 5 ml. of the nitroalkane, and 2g of ammonium acetate were added to 20 ml of ...
1
vote
1answer
101 views

Sephadex and purification of products [closed]

Sephadex is useful for the separation and purification of many natural products. Is it also useful for the separation and purification of artificial chemicals (in organic synthesis ) or not and why ?
3
votes
1answer
692 views

Malic acid 3-step synthesis

I was quite puzzled by the answer for this question in my Carboxylic Acids and Derivatives tutorial question set. It is question 6 (a), on the synthesis of malic acid, as shown in the image below. ...
-1
votes
2answers
482 views

How to make copper salicylate with electrolysis?

I am trying the following and it looks like it may be working, but I am not certain what the end product would be. Basic electrolysis setup: two cups distilled water, with 3 g of copper wire on anode,...
1
vote
1answer
2k views

What happens to the methanol formed by the hydrolysis of methyl 2-hydroxybenzoate (oil of wintergreen) when synthesising salicylic acid?

Here are the reaction equations for reference (you may recognise this as a preliminary step for the synthesis of aspirin). Steps for synthesis of salicylic acid: 1) methyl 2-hydroxybenzoate + sodium ...
1
vote
1answer
2k views

How to acid-wash sand?

I need some acid-washed sand to smooth out boiling in diethyl ether synthesis. I aready have pre-washed sand for general filtration purposes, but it is not labeled as acid-washed. Unfortunately, I ...
1
vote
1answer
662 views

Evaporation of concentrated formic acid and semi-concentrated sulfuric acid at room temperature

I recently looked at a reaction where CO is synthesized using formic acid and sulfuric acid, which seems to be one of the easier to control reactions for this, and obviously ventilation etc is ...
7
votes
0answers
213 views

How can I solve this synthesis?

I have this task to do: My solution: Is that possible? Can you please help me with the steps 2 and 3? This is what I did, but my teacher told me I should make the diketone (compound no. 5) from ...
4
votes
2answers
1k views

If acyl chlorides are reacted with aqueous ammonia, will carboxylic acids also be formed?

As part of my A-level chemistry course, I have been taught that an acyl chloride will react violently with water to produce a carboxylic acid and hydrochloric acid. I have also been taught that an ...
17
votes
1answer
574 views

Understanding the synthesis of twistane [closed]

What are the products P and Q? This was a question in my test series, but I don't have any experience with bridge head compound regarding the cis and trans transformation. I need help understanding ...
0
votes
1answer
415 views

In a two electrode system, is the applied current density referring to just the working electrode or to the auxiliary electrode as well?

I'm doing an experiment electrosynthesizing a polymer using a two electrode cell and it says to do it under 0.5 mA/cm^2. However, I am unsure if that means 0.5 mA per square centimeter of surface area ...
1
vote
1answer
153 views

Methylnitrobenzene ring formation Synthetic Route

I know the malonic ester is probably used to make propanoic acid or some carboxylic acid, and then joined to the methylnitrobenzene. But I just can't figure out what glues to the methyl. I know the ...
5
votes
1answer
65 views

Bridged ring system reduction through Wolf Kisher: Is it possible?

Is it possible for a ketone like this to undergo the Wolf Kishner mechanism? If so, what would be the product? It seems unlikely to me as disrupting the stable equitorial carbonyl seems unfavorable......
0
votes
1answer
137 views

How to synthesize tetrabutyl titanate from titanium dioxide powder?

How do you synthesize tetrabutyl titanate $(\ce{[CH3(CH2)3O]4Ti})$ from titanium dioxide ($\ce{TiO2}$) powder? As I know, we can get $\ce{TiO2}$ from tetrabutyl titanate, but how can we do the ...
2
votes
0answers
29 views

Nucleophilic Aromatic Substitution in ring with 4 Substituents

Does the chlorine still get substituted by OH in this case? I was also wondering, if it does get substituted, does anything happen between the ethanol substituent and the phenol -OH? I'm suspecting ...
0
votes
2answers
722 views

HCl/H2O with alkene: Which one reacts?

I think that the initial step forms a tertiary amine, which then in the presence of the ketone and trace acid undergoes nucleophilic addition. But then, for the $\ce{HCl/H2O}$ in the last step, which ...
3
votes
4answers
174 views

Chlorinating specifically one carbon on a symmetrical alcohol

The final target molecule is 1-chloro-2-amino propane. The amination step would be simple via reductive amination of 1-chloro-iso-propanone. Obtaining 1-chloro-iso-propanone would be from ...
1
vote
1answer
100 views

Biodiesel synthesis

I want to do the synthesis of biodiesel with the cooking oil (it contains colza and sunflower oils) in ethanol and KOH. After 1 hour of reaction, I let the solution to rest for 3 days. At this stage,...
-2
votes
1answer
647 views

Indigo synthesis from anthranilic acid [closed]

I am going to perform the synthesis of indigo via Heumann's methods which uses anthranilic or aniline as a starting materials. I am looking for the indigo synthesis procedure which includes all ...
6
votes
2answers
1k views

Producing sulphur dioxide for using in a reaction

I am doing an investigatory project on studying the coloured reactions of d-block and f-block elements. I have included two reactions that require sulphur dioxide as a part of my study. $$\ce{5SO2 ...
3
votes
0answers
159 views

N,N-Dimethyl-2-(indol-3-yl)glyoxylamide from indole

I would like to know how to obtain the following molecule, whose technical name should be something like N,N-dimethylindol-3-ylglyoxylamide (let's call it DMIG for short) One of the constraints being ...
-3
votes
1answer
86 views

Enthalpy of formaton [closed]

today I was doing a set of HW problems regarding enthalpy and stumble upon one problem that I found confusing.It was the standard enthalpy of formation for CaCO3 is -1207.6 kJ mol when 30.7 g of ...
2
votes
3answers
660 views

Conversion from t-butanol to alkene

How can I accomplish the above conversion? My thoughts: One way of introducing the double bond, would be using the appropriate Grignard Reagent after oxidation of t-butanol (somehow) I think that ...
4
votes
0answers
269 views

Substitution of a cyclic diether by a halogen

I’m in an organic synthesis class and I have to draw a mechanism for the reaction in the picture. At first I thought it was just forming a free radical but I haven’t been able to find any way to do ...
2
votes
0answers
3k views

Why is Red Phosphorous used in the Nagai Method? [duplicate]

The most common method of producing Dextromethamphetamine (Crystal Meth) is supposedly the Nagai Method, where Pseudoephedrine, Hydriodic acid and Red Phosphorous are refluxed overnight, producing a ...
2
votes
1answer
308 views

Is there a way to determine if a compound is oxygen or water sensitive?

The synthesis of $\ce{CoH[P(OPh)3]4}$ requires the use of an inert atmosphere e.g. nitrogen as the compound is air-sensitive. Is there any way to tell whether it is the oxygen or water vapour in the ...
-2
votes
0answers
31 views

What are the ways to abiogenically synthetesize Uric acid? [duplicate]

The only link I could find was, but I couldn't find it anywhere: Horbaczewski, Johann (1882). "Synthese der Harnsäure" [Synthesis of uric acid]. Monatshefte für Chemie und verwandte Teile anderer ...
3
votes
1answer
303 views

Synthesis of Hydrogen Fluoride

At almost 300°C, $\ce{CaF2}$ reacts with sulfuric acid and this reaction produces $\ce{HF}$. Is there any way to make a relatively dilute (10-20%) hydrofluoric acid with $\ce{CaF2}$ as the source of ...
-1
votes
1answer
861 views

Decarboxylation of alpha-amino acids to amines [closed]

In this reaction, what are the ideal circumstances? Which base would be a great choice? How much time does it take for tryptophan to fully decarboxylate? What is the ideal temperature for this type ...
2
votes
1answer
98 views

Tip of my tongue: what is the name of this process?

I remember back in Chemistry class, we did this thing where we would drop some liquid into a solvent. The moment it touched the solvent, it would turn into a gel sphere with the solvent inside it, and ...
5
votes
1answer
230 views

How is the yield of a complex organic synthesis defined?

I just watched the Periodic Table of Videos episode Deadly Strychnine that describes the history of this particularly challenging synthesis. University of Nottingham chemist Rob Stockman calls the ...
0
votes
2answers
4k views

Can benzaldehyde undergo chlorination (aka halogenation)?

I've read articles online and they rarely mention about chlorination of benzaldehyde but more on bromination. Also, I would like to know the catalyst used for this is FeCl3 or AlCl3? Thanks for your ...
2
votes
0answers
533 views

Why do we use the Schotten-Baumann synthesis method for the synthesis of amides?

Recently, I learnt about the Schotten-Baumann synthesis method. I know that this synthesis method was invented to overcome the problem of neutralising the acidic by-products of the amide synthesis ...
0
votes
1answer
267 views

Why is moist hydrogen made to react with chlorine to give hydrogen chloride?

Moist hydrogen reacts with chlorine in diffused sunlight to give out hydrogen chloride. Why is moist hydrogen used? Why not dry hydrogen?
10
votes
1answer
296 views

Were gold(II) complexes synthesized for the first time in 2017?

Recently in the Google news feed, I discovered this news: Gold stabilized in very rare oxidation state +II Missing golden link found: Divalent gold complex isolated for the first time in a ...
2
votes
0answers
478 views

Deprotection (debenzoylation) of glucose (sacharide) using NaOMe leads to hydrolysis glucose

I have a problem removing the benzoyl groups of my glucose moiety using sodium methylate (standard procedure). Indeed, the benzoyl groups are removed. However, a significant amount of glucose gets ...

1
3 4
5
6 7
14