Questions tagged [synthesis]

Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.

Filter by
Sorted by
Tagged with
0 votes
0 answers
25 views

Breakdown of addition polymers

We know that condensation polymers can be broken down by hydrolysis with the elimination of small water molecules. Then what about addition polymers? How can they be broken down into their monomers? I ...
Freeby Freeby's user avatar
-3 votes
1 answer
41 views

Synthesizing "Methyl 2-(2-oxopyrrolidin-1-yl)-2-phenylacetate" [closed]

I am a chemistry student, here I mapped out the steps one might take to synthesize Methyl2-(2-oxopyrrolidin-1-yl)-2-phenylacetate, a piracetam dirivitive. Please add any steps I might be missing and ...
Tom's user avatar
  • 1
0 votes
0 answers
43 views

Advise on performance vs cost of the Berkland-Eyde Process for direct synthesis of Nitric Acid from atrmospheric air

I am new to chemistry, having gone down an electronics route in my career, so I decided to pick up where my 'O' levels ended (many years ago) and make a better understanding of the topic a sort of ...
Jay M's user avatar
  • 101
0 votes
0 answers
43 views

Methanisation in the Haber Porcess

I've been reading up on the Haber process lately. In one such industrial case of ammonia synthesis, hydrogen is created through steam reforming, which creates some carbon monoxide. As the reaction ...
Jay Chen's user avatar
2 votes
0 answers
64 views

What is the product and mechanism of reducing a cyclohexanone derrivative with LAH?

I've been trying to figure out the product and mechanism of the reaction pictured below for a while now: I'm fairly sure that the first step is the reduction of the ketone by LAH, which results in a ...
HWABAG's user avatar
  • 29
3 votes
0 answers
78 views

Hydrolyse Phosphonate diester to free phosphonic acid under relatively mild conditions?

I want to hydrolyse a phosphonic acid diethylester to the corresponding free phosphonic acid. In the literature, it is described, that usually strongly basic or acidic conditions are utilized to ...
raptorlane's user avatar
1 vote
0 answers
76 views

Why did this synthesis of Aspirin fail?

I tried to synthesize acetylsalicylic acid(aspirin) by the method below. However, I definitely failed and got something unknown. The method used was: Add 2.5 g of salicylic acid(about 2494 mg), 3.0 ...
user139437's user avatar
-3 votes
1 answer
121 views

Production of sulphuric acid

To my knowledge, sulphuric acid is produced by complex industrial processes like contact process. The following structure shows a sulphate ion. I wonder why sulphuric acid cannot be produced through ...
Freeby Freeby's user avatar
2 votes
0 answers
49 views

Reduction of benzylic alcohol and halide using H2 and Pd

I am studying drug synthesis, and I found some examples that uses $\ce{H_2}$ and Pd/C or Pd/$\ce{BaSO_4}$ as catalytic hydrogenation reagents for reduction of alcohol or halide in benzylic position. ...
Krang Lee's user avatar
  • 993
2 votes
0 answers
50 views

Degradation of 4-MeO-Tetrahydrocarbazole

I recently synthesized 4-Methoxy-Tetrahydroxarbazole from 4-MeO-Phenylhydrazine and Cyclohexanone. The product had a off-white color directly after synthesis but was brown after standing over night at ...
arausch's user avatar
  • 31
1 vote
0 answers
41 views

Synthesis of 1-ethylcyclohexane-1,2-diol from cyclohexylethene

Here's my synthesis: HBr NaEtO OsO4/NMO But the problem is that for step 2, there are 3 possible alkene locations, with all of them having 3 substituents, so I would have all 3 forming (although 2 ...
Toast's user avatar
  • 11
0 votes
0 answers
58 views

Find the missing chemical structures in the reaction sequence

I came across the following question, where a set of reagents are used, starting from a carbohydrate derivative. I understand that this is some total synthesis reaction, but I cannot find which one. ...
Cyclopropanol's user avatar
5 votes
1 answer
212 views

Selective formation of enolates

I saw the following reaction on Modern methods of Organic Synthesis by Carruthers. The reaction is about the selective alkylation of trimethylsilyl enolates, and is shown below. However, I have some ...
Cyclopropanol's user avatar
1 vote
0 answers
33 views

Amidine synthesis from nitrile and dimethylamine using n-Buli as a base

I am making LiNMe2 using n-Buli (5.5 equiv.) and dimethylamine (5.0 equiv), -15 ºC, dry THF and under nitrogen atmosphere. I have been doing the reaction and I can observe conversion of starting ...
Bree's user avatar
  • 11
-1 votes
3 answers
100 views

Can any compound form into an amorphous solid?

I am curious whether it is possible or not to make any solution of a specific compound into a crystal lattice or into an amorphous solid? I know that crystals form under specific conditions but seem ...
Brian Blumberg's user avatar
1 vote
0 answers
50 views

TMSiBr and Oxalylchloride for ester cleavage

I am wondering what is the advantage of using TMSiBr do perform an ester cleavage in comparison to perform chlorination first for example with oxalylchloride or thionylchloride and than add water?
raptorlane's user avatar
1 vote
0 answers
41 views

Esterification of phosphonic acid chloride is working with isoprenol but not with prenol

I am performing an esterfication reaction between an activated phosphonic acid (chloride) and a series of alcohols. Until now, I was not able to make the reaction work with prenol, while isoprenol is ...
raptorlane's user avatar
-4 votes
1 answer
66 views

Reaction of eugenol with concentrated hydrobromic acid in the presence of gaseous hydrogen bromide [closed]

DISCLAIMER: I am not using any of this information to commit a crime, my university has a license from the relevant authorities to investigate clandestine chemical procedures. We are investigating an ...
user1754943285's user avatar
1 vote
0 answers
31 views

Avoid triethylphosphate as a side product during P-C-P coupling reaction with diethylchlorophosphate with LDA

I have a reaction in which I perform a deprotonation of an acidic proton at a phosphate and later do a P-C-P coupling. The coupling partner is diethylchlorophosphate. Deprotonation is performed with ...
raptorlane's user avatar
5 votes
0 answers
42 views

Specific question about the total synthesis of B-12

In the process of synthesizing B-12, Woodward & Co. produce an intermediate thioether they refer to as Type I. "Type I because we found early in working with these substances that they were ...
GMoss's user avatar
  • 311
2 votes
2 answers
305 views

Are these reactions in synthesis of melamine correct?

I found the Wikipedia article for melamine to be incorrect in "synthesis and reaction" section; so I decided to edit it. But on the other hand I'm not sure my assumption to be correct that ...
Walter Heisenberg White's user avatar
2 votes
0 answers
102 views

Alternative synthesis for LK-99 proposed room-temperature superconductor

This is probably not the best place to post this, but I'm posting in case it might reach the right people who could give this a try. The current synthesis for the proposed LK-99 superconductor is a ...
MichaelK's user avatar
  • 400
1 vote
1 answer
34 views

Production SnO2 nanoparticles through chemical co-precipitation method: chemical equation of the reaction

In this paper, the production of $\ce{SnO2}$ nanoparticles through the chemical co-precipiation method is described using $\ce{SnCl2·2H2O}$ as a precursor. According to their experimental section, $\...
user21390097's user avatar
1 vote
1 answer
130 views

How do I synthesize salicylic acid?

I'm looking to synthesize salicylic acid in my school laboratory for an investigatory project. The Kolbe's reaction looks promising: Any suggestions on where to get the $\ce{CO2}$ from? Will the ...
Aditya Kumar Panda's user avatar
0 votes
1 answer
202 views

Magnesium chloride to citrate conversion (reaction/synthesis)

How would one prepare magnesium citrate from magnesium chloride and citric acid? Will it work if I just heat a mixture of magnesium chloride and citric acid in water? I'd expect HCl to vaporize off. ...
Mister Sir's user avatar
0 votes
0 answers
77 views

Color change when heating organic compound

I did just attend a lab class where I should synthesize 3,6-dibromo- N-propylcarbazole from N-propylcarbazole by bromination. Once, the bromination was over the color of the reaction content was ...
maniboy's user avatar
3 votes
0 answers
82 views

How does the synthesis of [18]annulene proceed stepwise?

Finding good literature on the synthesis of [18]annulene is challenging, as most sources are well old and quite archaic, so I was hoping some explanation in regard to the mechanism of synthesis. My ...
Evamentality's user avatar
2 votes
0 answers
74 views

Protecting Thiol group in presence of alcohol

What protecting group can I use that will protect the thiol in the presence of an alcohol? Is there a set of conditions, or a group that I can use that is selective to the thiol over the alcohol? I am ...
Maya H's user avatar
  • 21
1 vote
0 answers
35 views

Is it possible to prevent elimination during Diels Alder reactions using Danishevsky's diene (or variants)?

Are there examples of keeping the methoxy group and then using it to perhaps do radical chemistry without eliminating to the enone?
sweetandtangy's user avatar
-4 votes
1 answer
67 views

Finding chromium

If I were to go back in time to pre-industrial Earth, and I wanted to make stainless steel, would there be a way to find chromium and/or chromite? It doesn't matter what chemical form the chromium ...
Jim Clay's user avatar
-4 votes
1 answer
100 views

How to synthesize lanthanum(III) chloride & Cerium(III) chloride from their oxides?

Interested in obtaining anhydrous lanthanum/cerium chlorides $\ce{La2O3}$ / $\ce{СeO2}$ in a flow of carbon tetrachloride at 500 degrees $\ce{La2O3}$ / $\ce{CeO2}$ with ammonium chloride when heated (...
1st32's user avatar
  • 1
10 votes
1 answer
518 views

What is the best way to deprotonate a methyl group?

I am attempting to deprotonate the methyl group on 2-methylbenzo[d]thiazol-6-ol (hydroxyl group is protected with a silyl group) in order to attach a phosphate group in the form of diethyl ...
Edward Harvey-Latham's user avatar
5 votes
3 answers
1k views

Why will changing the solvent crack the column for column chromatography?

When we perform column chromatography with silica to purify the reaction crude product, we sometimes need to change the solvent system to better extract our target product. For example, changing from ...
Richie12138's user avatar
0 votes
1 answer
179 views

What are the reactions between Zinc acetate dihydrate and Methoxyethanol? [closed]

I am synthesizing a sol-gel solution with Zinc acetate dihydrate + Methoxyethanol and ethanolamine as stabilizer, and I wonder what are the reactions that are taking place in the process. Could you ...
Chemistry's user avatar
3 votes
2 answers
137 views

How is NADH or NADPH produced in industrial chemical synsthesis?

I am trying to find out how NADH or NADPH are produced in bulk. These molecules are very important biologically, however, they are also sold as chemical reagents and produced in large quantities. How ...
C.X.F.'s user avatar
  • 1,821
1 vote
0 answers
43 views

Cause and Prevention of Palladium Mirror in Stille Coupling

I am conducting some monomer and polymer syntheses using Stille coupling or other palladium-based coupling. I usually use the combination of $\ce{Pd_2(dba)_3}$ and $\ce{P(o-tol)_3}$ in Stille coupling,...
Krang Lee's user avatar
  • 993
2 votes
1 answer
121 views

How do you synthesize 1-fluoro-4-(tribromomethyl)benzene from toluene

I got this question from an o-chem II exam which kinda puzzles me a bit My proposed path is: which doesn't seem to be correct. Is there any other way within the knowledge of o-chem I & II?
frostbite's user avatar
0 votes
1 answer
84 views

Why is the sp3-sp3 reductive elimination between the R1 and norbornene in the Catellani Cycle ''not favorable''?

I have recently started reading a book about C-H activation and I cannot figure out why in the Catellani reaction cycle the R1-norbornene reductive elimination side reaction which can be a major issue ...
TheBorcanu's user avatar
0 votes
1 answer
137 views

Synthesis of a Substituted Indane

From the starting reactants given as the sole carbon source: We need to synthesis the following compound (we can use any inorganic reagents). Here is what I tried so far, but I don't think it looks &...
Theo H.'s user avatar
  • 39
-3 votes
1 answer
47 views

synthetic procedure for 1,3,4 thiadiazole from acylhydrazide [closed]

I wanted to synthesize 1,3,4 thiadiazole-2- thiol substituted to benzoic acid the reaction has to happen in such a way that the "acid hydrazide" group of benzoic acid hydrazide has to ...
Dina's user avatar
  • 7
3 votes
0 answers
56 views

Halogenation of organic acid derivatives

Chloropicrin can be produced through the reaction of sodium hypochlorite with nitromethane. On the surface, this seems to me to proceed through a mechanism analogous to the haloform reaction, with one ...
user73910's user avatar
  • 1,234
0 votes
1 answer
174 views

Can we use potassium hydroxide to decarboxylate potassium benzoate to benzene?

I know the famous reaction: I was thinking of extension of this reaction to other salts of Benzoic Acids such as: $$\ce{Potassium Benzoate + KOH ->[CaO,Δ] Benzene + K2CO3}$$ Is this reaction ...
CHEMUMAN's user avatar
-2 votes
1 answer
272 views

What does it mean stir at room temperature overnight? [closed]

It was mentioned in synthetic procedure to "stir at room temperature overnight". What does this mean? (I want the exact duration for how long should I keep stirring.) How is it possible to ...
Dina's user avatar
  • 7
2 votes
0 answers
57 views

How to add any polymer to azobenzene?

I want to make a polymer by adding two polymeric substituent groups to azobenzene (I would like only N-azobenzene-N where N is a polymer and repeats). I have been reading about how they make the ...
Juan Carlos Dominguez Solis's user avatar
4 votes
1 answer
764 views

Does germanium(IV) chloride have to be handled under inert atmosphere?

I am finding conflicting information on the proper handling of germanium(IV) chloride. Is the liquid air/moisture sensitive? Does $\ce{GeCl4}$ have to be handled in a glove box?
seisenberg19's user avatar
1 vote
0 answers
66 views

Erythritol oxidation using acidified KMnO4

I have recently experimented with erythritol oxidation my primary aim was to make glyoxal. However regarding the nature and structure of erythritol several other side-products were also observed one ...
Copper Chopper's user avatar
0 votes
1 answer
39 views

Is there any calcium carbonate analogue drawing carbon from dry air?

Is there a nonliving (wood does not count) substance or process that accretes a solid material by withdrawing carbon from the air, in a manner analogous to calcium carbonate being accreted from ...
Mark Besser's user avatar
3 votes
0 answers
79 views

Why does Bachmann reaction differ in batch characteristics as opposed to flow characteristics

I have studied this reaction for over a year and it makes zero sense. When synthesizing HMX from Bachmann reaction, an important intermediate is DPT. DPT is formed by reaction of nitric and hexamine ...
Pulkit Sharma's user avatar
0 votes
2 answers
222 views

Synthesis and retrosynthetic analysis of dicyclohexylamine

I need to consider the retrosynthetic analysis and synthesis of dicyclohexylamine. For the retrosynthetic analysis, I have relied on the method of disconnections, which consists in splitting the ...
Carlos's user avatar
  • 607
1 vote
0 answers
59 views

Functional groups in graphene oxide

There is already a large number of literature on graphene oxide stating that the number of epoxy groups is quite similar to the number of ethyl groups. However, I was wondering if the number of ...
Roshan Shrestha's user avatar

1
2 3 4 5
17