Questions tagged [retrosynthesis]
The retrosynthesis tag has no usage guidance.
7
questions
4
votes
0
answers
59
views
Retrosynthesis of 1-(3-chloro-5-nitrophenyl)-2,2-dimethylpropan-1-one
I was tasked with figuring out the order of attaching the functional groups to a benzene ring for the synthesis of 1-(3-chloro-5-nitrophenyl)-2,2-dimethylpropan-1-one:
I propose the following order:
...
0
votes
2
answers
222
views
Synthesis and retrosynthetic analysis of dicyclohexylamine
I need to consider the retrosynthetic analysis and synthesis of dicyclohexylamine.
For the retrosynthetic analysis, I have relied on the method of disconnections, which consists in splitting the ...
- 607
0
votes
0
answers
71
views
Retrosynthesis of (1S,2R)‐1‐isopropyl‐2,4‐dimethylcyclohexane
I think that retrosynthesis of (1S,2R)‐1‐isopropyl‐2,4‐dimethylcyclohexane involves the opening of an epoxide, to control the regiochemistry in order to achieve the trans-configuration via an SN2 ...
- 73
7
votes
1
answer
454
views
Retrosynthesis of (2E)-1-(2,4-dimethylphenyl)-3-(thiophen-2-yl)prop-2-en-1-one
I am struggling to find a way to disconnect this molecule and I am unsure of the order:
First, I was thinking of disconnecting the C=C of the α,β-unsaturated carbonyl. Then for the thiophene group ...
- 73
1
vote
0
answers
66
views
Retrosynthesis of {6-[2-(benzylamino)ethyl]-1,4-dihydropyrimidin-4-yl}methanol
I have {6-[2-(benzylamino)ethyl]-1,4-dihydropyrimidin-4-yl}methanol (at the top) and have to make the retrosynthesis steps for my class.
I tried different things but I'm not sure about it. In 1 you ...
- 11
5
votes
2
answers
347
views
How can we synthesize this cycloester, starting with methyl 4-phenylbutanoate?
I was wondering how to realize following synthesis:
I am struggling with this one; for sure, this has something to do with the benzyl position which is particularly reactive, and something ...
user115162
4
votes
0
answers
160
views
retrosynthesis gamma-hydroxy ketone
One of the sections about retrosynthesis in Warren's book addresses how to access $\gamma$-hydroxy carbonyl compounds like ZM181. This is again one of the examples to advice the reader to check the ...
- 28.4k