Questions tagged [retrosynthesis]

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Retrosynthesis of (1S,2R)‐1‐isopropyl‐2,4‐dimethylcyclohexane

I think that retrosynthesis of (1S,2R)‐1‐isopropyl‐2,4‐dimethylcyclohexane involves the opening of an epoxide, to control the regiochemistry in order to achieve the trans-configuration via an SN2 ...
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Retrosynthesis of (2E)-1-(2,4-dimethylphenyl)-3-(thiophen-2-yl)prop-2-en-1-one

I am struggling to find a way to disconnect this molecule and I am unsure of the order: First, I was thinking of disconnecting the C=C of the α,β-unsaturated carbonyl. Then for the thiophene group ...
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Retrosynthesis of {6-[2-(benzylamino)ethyl]-1,4-dihydropyrimidin-4-yl}methanol

I have {6-[2-(benzylamino)ethyl]-1,4-dihydropyrimidin-4-yl}methanol (at the top) and have to make the retrosynthesis steps for my class. I tried different things but I'm not sure about it. In 1 you ...
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5 votes
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How can we synthesize this cycloester, starting with methyl 4-phenylbutanoate?

I was wondering how to realize following synthesis: I am struggling with this one; for sure, this has something to do with the benzyl position which is particularly reactive, and something ...
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4 votes
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retrosynthesis gamma-hydroxy ketone

One of the sections about retrosynthesis in Warren's book addresses how to access $\gamma$-hydroxy carbonyl compounds like ZM181. This is again one of the examples to advice the reader to check the ...
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