Questions tagged [retrosynthesis]

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Retrosynthesis of {6-[2-(benzylamino)ethyl]-1,4-dihydropyrimidin-4-yl}methanol

I have {6-[2-(benzylamino)ethyl]-1,4-dihydropyrimidin-4-yl}methanol (at the top) and have to make the retrosynthesis steps for my class. I tried different things but I'm not sure about it. In 1 you ...
5
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2answers
305 views

How can we synthesize this cycloester, starting with methyl 4-phenylbutanoate?

I was wondering how to realize following synthesis: I am struggling with this one; for sure, this has something to do with the benzyl position which is particularly reactive, and something ...
3
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0answers
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How can we synthesize 1,1-dichloro-2,2,3,3-tetramethylcyclopropane from pivaldehyde?

How to synthesize 1,1-dichloro-2,2,3,3-tetramethylcyclopropane from pivaldehyde? I don't know how to close the ring structure: Should we synthesize an epoxide first? I'd appreciate any tips regarding ...
4
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0answers
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retrosynthesis gamma-hydroxy ketone

One of the sections about retrosynthesis in Warren's book addresses how to access $\gamma$-hydroxy carbonyl compounds like ZM181. This is again one of the examples to advice the reader to check the ...