Questions tagged [organophosphorus-compounds]

For questions about the synthesis, properties, or reactivities of organic compounds containing phosphorus; or about reactions in which such compounds are used.

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Why is Chlormephos highly toxic despite requiring metabolic activation?

According to the book "The Chemistry of Organophosphorus Pesticides", the insecticide Chlormephos (S-(chloromethyl) O,O-diethyl phosphorodithioate) has an oral LD50 in rats of 7 mg/kg. For ...
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Purification of Red Phosphorus

The Boring Stuff I'm well acquainted with various fields of science & engineering, but my foray into the world of chemistry is relatively recent. I'm in a location (probably most of us are to some ...
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Isomerization of phosphorylated 2-imino-1,3-dioxalanes into phosphorylated cyclic carbamates

I found a patent dating back to the Soviet Union. The patent number is 256764, and the patent describes the synthesis of phosphorylated cyclic carbamates. Here is a section of the patent, followed by ...
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Differences in Novichok agent mass spectra

As we have all heard, in 2018, a series of poisonings with a nerve agent alleged to be of the Novichok series was carried out on British soil. It is claimed that the agent used was A-234. However, a ...
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Differences in efficacy of oxime reactivators in organophosphate poisoning

Compounds containing an oxime functional group, such as 2-PAM and obidoxime, are used in the treatment of poisoning with organophosphorus compounds. These oximes reactivate the enzyme ...
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Phosphonate reaction with oxides and their stability?

I have read some papers stating that $\ce{SiO2}$ surfaces can bind phosphonates, but in water they hydrolyse. However, for $\ce{Si}$ surfaces, they are stable in water. In both cases, the reaction ...
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Reaction of phosphonates with conjugated carbonyl compounds

I was wondering whether the phosphonate ion would do a Michael addition on to the double bond rather than attacking the $\ce{C=O}$ bond to form the alkene product as it usually does (e.g. in a Horner–...