All Questions
15 questions
2
votes
0
answers
110
views
Is there a formal definition of “identical” molecules?
I was reading about atropisomers and their impacts on drug design, and I started wondering whether we have a formal definition for identical molecules. Atropisomers are not the same molecules because ...
- 335
0
votes
0
answers
56
views
Translating from milligrams in the pill to Ki at the receptor
Many places (e.g. Wikipedia) report the action of a drug on the various receptors, transporters, ion channels, and the like in terms of the Ki(nM). (This is for drugs that act primarily through such ...
- 165
3
votes
0
answers
138
views
How stable is Remdesivir when vial vacuum is broken and/or it is reconstituted with sterile water?
I was recently looking at how long can Remdesivir be stored in its different forms.
I came up across several articles provided by the FDA and Gilead Sciences and others.
What caught my eye was the ...
- 89
2
votes
1
answer
47
views
API formulations - are excipients required
I have the following API's
Itraconazole, Ivermectin, Fenofibrate, Pyrvinium Pamoate, Sulfasalazine, Artesunate, All-Trans Retinoic Acid, Doxycycline, Atovaquone, Extremestane, Syrosingopine and ...
- 21
0
votes
0
answers
34
views
Racemic mixture vs enantiomers in drugs [duplicate]
a racemic mixture has 50-50% of the 2 different enantiomers. There are racemate drugs out there in the world. The misunderstanding I have is that usually 1 out of the 2 enantiomers molecules have a ...
- 529
15
votes
2
answers
3k
views
Why do most drugs (eg: oxycodone) have seemingly arbitrary names?
How do some medicines derive their names?
For instance, is the name oxycodone somewhat arbitrary? I am not well-versed in Chemistry (1st semester student) but does the prefix oxy- imply some ...
- 423
8
votes
1
answer
540
views
How does Rosuvastatin 5 S-lactone form in human body?
I've searched lots of free resources online but cannot find the answer.
the top compound is Rosuvastatin.
Some websites say it is metabolized by the enzyme CYP2C9,
but I can't figure out how a ...
- 251
1
vote
0
answers
89
views
Is there a drug that can encapsulate benzene in the liver? [closed]
I'm doing a project on the prevention of leukemia and upon researching on the metabolism of benzene in the liver (since high levels of benzene can lead to leukemia), I thought of a question that was ...
2
votes
1
answer
4k
views
What is the industrial yield of paracetamol?
Anyone know how I can find out the typical yield of paracetamol (acetaminophen) from the acetylation of 4-aminophenol?
Please provide the source if you happen to know!
- 1,799
4
votes
0
answers
632
views
degradation of sertraline
The picture above is a drug called Setraline. Suggest a likely mode of degradation of sertraline hydrochloride alone in aqueous solution, giving likely structures of the degradation products.
From my ...
- 149
1
vote
2
answers
105
views
Are ethyl iodophenylundecylate and Ethyl-10-(Iodophenylundecanoate) the same compound?
I have no understanding of chemistry, so these to chemical formulas mean nothing to me. What I am trying to ascertain is are these compounds the same? If not, what differences are there especially if ...
2
votes
1
answer
1k
views
Why does lactulose turn dark?
Why does the standard 10gm/15ml lactulose solution turn dark when exposed to heat above 30 degrees Celsius?
This is probably a simple question. It is funny that the warnings/important information on ...
2
votes
1
answer
553
views
name of a pharmaceutical drug used in dentistry that has Ionic bonding? and how this bounding is made?
Hello I am looking for this information and I did not find anything, the closest thing I have found it is Fluorocarbon, but I think it is wrong, does anybody know?.
Help really appreciated I am still ...
- 123
14
votes
3
answers
3k
views
What chemical properties make LSD so psychoactive?
Lysergic acid diethylamide (LSD) is a well known hallucinogen and (usually) illegal psychoactive drug with the structure below:
The drug is active is doses measured in micrograms in contrast to many ...
- 37.8k
17
votes
1
answer
1k
views
Why does the sulfone ring in tazobactam open when the lactam is hydrolyzed?
One of the drugs I work with is a beta-lactam (4-membered ring with an amide bond) fused to a sulfone ring, tazobactam.
It's relatively stable in water; the lactam is not significantly hydrolyzed ...
- 2,573