All Questions
Tagged with organic-chemistry pharmacology
25 questions
2
votes
1
answer
120
views
What can I do if a peptide won't go in solution in a biological assay?
I have working on the realisation of on assay, that is intended to examine the activity of a protein. The assay works in a way, in which the product of the target enzyme is transfered by a support ...
- 829
2
votes
0
answers
110
views
Is there a formal definition of “identical” molecules?
I was reading about atropisomers and their impacts on drug design, and I started wondering whether we have a formal definition for identical molecules. Atropisomers are not the same molecules because ...
- 335
1
vote
0
answers
98
views
What are the compounds that this article refers to?
The linked article studies the effects of a set of organophosphorus compounds on the bioelectrical activity in the digestive system. The OP compounds studied are referred to in the abstract as IMFF, ...
- 1,274
0
votes
0
answers
56
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Translating from milligrams in the pill to Ki at the receptor
Many places (e.g. Wikipedia) report the action of a drug on the various receptors, transporters, ion channels, and the like in terms of the Ki(nM). (This is for drugs that act primarily through such ...
- 165
3
votes
0
answers
138
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How stable is Remdesivir when vial vacuum is broken and/or it is reconstituted with sterile water?
I was recently looking at how long can Remdesivir be stored in its different forms.
I came up across several articles provided by the FDA and Gilead Sciences and others.
What caught my eye was the ...
- 89
2
votes
1
answer
47
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API formulations - are excipients required
I have the following API's
Itraconazole, Ivermectin, Fenofibrate, Pyrvinium Pamoate, Sulfasalazine, Artesunate, All-Trans Retinoic Acid, Doxycycline, Atovaquone, Extremestane, Syrosingopine and ...
- 21
-2
votes
2
answers
2k
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Chemical difference between dexedrine and methamphetamine [closed]
I am a newbie at chemistry and wondering what the key difference between dexedrine and methamphetamine HCL is. I know that methamphetamine has an extra methyl group compared to Adderall. But what ...
- 27
1
vote
0
answers
60
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Hydrolysis of phosphoryl-oximes
When acetylcholinesterase that has been inhibited by an organophosphorus compound is reactivated by an oxime, a phosphoryl-oxime is formed, which is then somehow hydrolyzed in the blood.
One study ...
- 1,274
0
votes
0
answers
34
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Racemic mixture vs enantiomers in drugs [duplicate]
a racemic mixture has 50-50% of the 2 different enantiomers. There are racemate drugs out there in the world. The misunderstanding I have is that usually 1 out of the 2 enantiomers molecules have a ...
- 529
4
votes
0
answers
46
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Unknown possibly handmade glassware- description in information below
Okay, Another random item from the cupboard (unknown users or discipline of life sciences unknown) could be anything up to 40 years old....
This appears to be a 2 neck quickfit adapter (B19 and B14) ...
- 99
-1
votes
1
answer
49
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Could there be a class of drugs beyond, similar to barbiturates and benzodiazepines? [closed]
I'm talking about group of drugs similar to them but different though.Is there anything beyond benzodiazepines?
- 101
-1
votes
1
answer
66
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Trichloroacetyl carbamate cleavage to unsubstituted carbamate
I studied that when alcohol is treated with isocyanate and then undergone hydrolysis (or methanolosis), carbamate is formed. But when we use carbamate as trichloroacetyl isocyanate, why hydrolysis ...
- 1
15
votes
2
answers
3k
views
Why do most drugs (eg: oxycodone) have seemingly arbitrary names?
How do some medicines derive their names?
For instance, is the name oxycodone somewhat arbitrary? I am not well-versed in Chemistry (1st semester student) but does the prefix oxy- imply some ...
- 423
8
votes
1
answer
540
views
How does Rosuvastatin 5 S-lactone form in human body?
I've searched lots of free resources online but cannot find the answer.
the top compound is Rosuvastatin.
Some websites say it is metabolized by the enzyme CYP2C9,
but I can't figure out how a ...
- 251
1
vote
0
answers
89
views
Is there a drug that can encapsulate benzene in the liver? [closed]
I'm doing a project on the prevention of leukemia and upon researching on the metabolism of benzene in the liver (since high levels of benzene can lead to leukemia), I thought of a question that was ...
2
votes
1
answer
4k
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What is the industrial yield of paracetamol?
Anyone know how I can find out the typical yield of paracetamol (acetaminophen) from the acetylation of 4-aminophenol?
Please provide the source if you happen to know!
- 1,799
0
votes
1
answer
448
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Does CDCl3 also Knock People Out?
I know that chloroform can be used to make people unconscious, but would that also work with deuterated chloroform, $\ce{CDCl3}$?
My instinct is "yes", but I'm not sure I'm willing to try this ...
- 1,143
4
votes
0
answers
632
views
degradation of sertraline
The picture above is a drug called Setraline. Suggest a likely mode of degradation of sertraline hydrochloride alone in aqueous solution, giving likely structures of the degradation products.
From my ...
- 149
1
vote
2
answers
105
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Are ethyl iodophenylundecylate and Ethyl-10-(Iodophenylundecanoate) the same compound?
I have no understanding of chemistry, so these to chemical formulas mean nothing to me. What I am trying to ascertain is are these compounds the same? If not, what differences are there especially if ...
6
votes
2
answers
761
views
How does sugammadex (a modified cyclodextrin) draw rocuronium into its lipophilic cavity?
Sugammadex is a modified cyclodextrin: 8 member sugar ring with carboxyl thioether extensions. Rocuronium is an aminosteroid, 4 steroid rings and one protonated amine group.
Sugammadex binds ...
- 549
2
votes
1
answer
1k
views
Why does lactulose turn dark?
Why does the standard 10gm/15ml lactulose solution turn dark when exposed to heat above 30 degrees Celsius?
This is probably a simple question. It is funny that the warnings/important information on ...
3
votes
2
answers
7k
views
How do the fields of medicinal chemistry, pharmaceutical chemistry, pharmacy, and pharmacology differ?
I would like to know what the difference between medicinal chemistry, pharmaceutical chemistry, pharmacy and pharmacology. All of them seem to involve the development of drugs, so I am confusd as to ...
- 341
2
votes
1
answer
553
views
name of a pharmaceutical drug used in dentistry that has Ionic bonding? and how this bounding is made?
Hello I am looking for this information and I did not find anything, the closest thing I have found it is Fluorocarbon, but I think it is wrong, does anybody know?.
Help really appreciated I am still ...
- 123
14
votes
3
answers
3k
views
What chemical properties make LSD so psychoactive?
Lysergic acid diethylamide (LSD) is a well known hallucinogen and (usually) illegal psychoactive drug with the structure below:
The drug is active is doses measured in micrograms in contrast to many ...
- 37.8k
17
votes
1
answer
1k
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Why does the sulfone ring in tazobactam open when the lactam is hydrolyzed?
One of the drugs I work with is a beta-lactam (4-membered ring with an amide bond) fused to a sulfone ring, tazobactam.
It's relatively stable in water; the lactam is not significantly hydrolyzed ...
- 2,573