Questions tagged [elimination]

Questions whose main focus is on E1, E2, E1cb, or any other type of elimination reaction.

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Why does alpha-carbon substituents increase the rate of E2 reactions?

The reason for more reactivity of more substituted alkyl halides for E2 Reaction is said to be due to the more stability of its more substituted alkene character having transition state but here (...
D13G's user avatar
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Will hydride shift occur?

Which of the following alkyl halides give most complex mixture of alkene in an E2 reaction? 1-bromobutane 2-bromopentane 3-bromopentane 2-bromo-2-methylbutane I did hydride shift for the 1st option ...
Sriven Ravi Charan's user avatar
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Why can't ethoxide ion act as nucleophile?

Consider the reaction of chlorocyclohexane with ethoxide in a suitable inert solvent. The major product according to my textbook is cyclohexene, which implies E2 reaction pathway. Why not SN2? $\ce{...
Leibniz-Z's user avatar
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Enamine formation mechanism. Can't there be alternatives?

I'm studying organic chemistry, more specifically the imines and enamines. I've read about the mechanism of formation of enamine from a generic ketone and a question popped up in my mind. The ...
Paolo Larocca's user avatar
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how does enolate affect an elimination reaction?

From my class: But why wouldn't the reaction proceed through this way, which makes more sense? Since the reaction above generates an enolate bearing a negative charge first, making the molecule less ...
HypnoticBuggyWraithVirileBevy's user avatar
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Which substrates will undergo an E2 reaction to give a (Z) alkene?

What I do know: E2 reactions are concerted and have an anti-coplanar transition state, where the leaving group and the hydrogen being abstracted have a dihedral angle of 180 degrees. What I don't ...
Dylan's user avatar
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2 votes
2 answers
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NaOt-Bu + chloroethane

What is the major product formed by reaction of sodium tert-butoxide and chloroethane? I thought NaOt-Bu is a bulky base and the major product will be ethene due to E2. But the answer says t-butyl ...
Shub's user avatar
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Which 1,2-methylene shift is more favourable in ring expansions where ring has substituents

In the above reaction, first the -OH group is protonated after which it leaves creating a carbocation intermediate as shown Now, ring expansion is a more favourable rearrangement, however there is a ...
Pravimish's user avatar
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Why will a lone pair from H2O not attack a C+ atom in elimination reaction?

In step three of reaction between H2SO4 and alcohol, why will the H2O attack the H atom instead of the C+ atom? they both have positive charge and in nucleophilic substitution reactions the c+ atom is ...
monke's user avatar
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What would be the product(s) when 2-iodobutane is heated with tertiary butoxide?

The following question from Black Book Organic Chemistry IIT JEE Advanced Level Papers [1]: Choose the correct option(s) among the following about [P]: A) Two C−H bonds in [P] are involved in ...
Ayush Shankaram's user avatar
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Does E1 mechanism always imply first order reaction?

Oxford University Press, Okuyama & Maskill: Organic Chemistry — Chapter 13: Multiple Choice Questions, Question 1: Which of the following statements regarding the E1 mechanism is wrong? a) ...
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Does E1cB take place over here?

I formed this product (reason: alkene has 6 alpha hydrogens) ----> However, it turns out, this is the answer: The reason why I suspect this is e1cb is because NO2 could stabilize the carboanion (...
Meet Lalwani's user avatar
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What kind of rearrangement happens between 2,2,5-trimethylcyclopentanol and concentrated sulfuric acid?

Question: My attempt: After getting the carbocation after protonation, in order to form a more stable alkene, it rearranged the methyl group on the adjacent carbon so as to get the alkene in the ...
asymptotes's user avatar
2 votes
2 answers
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Reactivity of 1-bromo-4-tert-butylcyclohexane isomers with methanol

(1s,4s)-1-bromo-4-tert-butylcyclohexane (1) and (1r,4r)-1-bromo-4-tert-butylcyclohexane (2) are heated (E2) with $\ce{NaOCH3}/\ce{CH3OH}.$ Which isomer will react faster? What will change when $\ce{...
Stormin nn's user avatar
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Difference between SN' and elimination reactions

My professor has recently taught us about SN' reaction example in which 3-bromo-3-methyl-but-1-ene was reacted with with KCN to yield 4-methyl-pent-3-ene-nitrile as the major product.When I asked him ...
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5 votes
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Why is the major product of an elimination reaction an alkyne and not the diene?

1,2-Dibromopropane and KOH react together to form propyne. But I wondered if 1,2-propadiene was also being produced since the there is also a proton on the $\ce{CH3}$ group to be used in the ...
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Mechanism of this addition-elimination process

In Part 1 of the synthesis of Maoecrystal V (found on synarchive), the last step subjects a $\ce {\alpha, \beta}$-unsaturated ketone to $\ce {I2}$ and pyridine, as shown below: I am wondering what is ...
Tan Yong Boon's user avatar
2 votes
1 answer
108 views

Conversion of cyclohepta-1,3-diene to cyclohepta-1,3,5-triene

In the landmark synthesis of tropinone by Willstatter in 1901, an interesting step involves the use of $\ce {Br_2}$, quinoline to convert cyclohexa-1,3-diene to cyclohexa-1,3,5-triene. In the scheme ...
Tan Yong Boon's user avatar
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Why do active methylene compounds give Sn2 reactions?

I dont understand why they are strong nucleophiles when the negative charge is resonance stabilised. Also it is bulky, is there any chance of elimination?
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Reaction of aqueous KOH and alcoholic KOH with alkyl halide [duplicate]

CONTEXT: Here's reaction of alkyl halide with aqueous $\ce{KOH}$ and here's the reaction for dehydrohalogenation by alcoholic $\ce{KOH}$ Question Initially $\ce{KOH}$ is aqueous. On reacting with ...
Platyhelminthes's user avatar
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Can methoxide ion be used as a base in an E1 elimination reaction?

This one problem given in my textbook is confusing because all I know is we can use a weak base for an E1 Reaction. But the reagent given is a methoxide ion. I thought the answer would B but it is C. ...
Chirag N's user avatar
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1 answer
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Mechanism of acid-catalyzed ring opening of a cyclopropane ring

I have a question regarding following synthesis which apparently only needs a sour medium to occur: What exactly happens as a mechanism? What I thought was: The alcohol group gets protonated and ...
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E1CB mechanism with replacement of hydrogen step?

In this question by Jay, one of the sub parts of the total question has the following reaction identified as $\ce{E1CB}$ pathway: $$\ce{Ph-CH2-CH2Br} \text{ on treatment with } \ce{C2H5OD/C2H5O-} \\ \...
Reine Abstraktion's user avatar
8 votes
1 answer
694 views

Mechanism of reaction of ketones with isoalkanes under conc. sulfuric acid and heat

Taken from the book of GOC by Dr. O.P Tandon, Himanshu Pandey, Dr. A.K. Virmani, Can anyone elaborate on the mechanism?
Neha's user avatar
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3 votes
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Does Ei or pyrolytic elimination reaction undergo carbocation rearrangement?

I've read about E1 reaction (unimolecular elimination reaction) which forms the most stable carbocation first and then undergoes the elimination. Ei is also mentioned to be "unimolecular" in ...
Neha's user avatar
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8 votes
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When is Zaitsev product formed in pyrolytic elimination reaction?

I recently came across a problem of choosing which product to be made in case of pyrolytic elimination reactions. I was taught that usually Hoffman products are formed in such reactions. For e.g.: In ...
davacd's user avatar
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Elimination reaction mechanism decision (order = 1 or 2)

Match the following: \begin{array}{} & \textbf{Column I}&&\textbf{Column II} \\ \text{(A)} & \ce{CH3-CHBr-CD3} \text{ on treatment with alc. KOH gives}& \text{(P)}& \text{E1 ...
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Determining if the product would be cis or trans after an anti elimination on fischer projections

I find these kind of problems really confusing for some reason, but I saw a way on the web and tried doing it that way: I considered the basic Fischer operations (Vertical: Below the plane of paper, ...
Prajwal Tiwari's user avatar
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1 answer
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Can dehalogenation reaction occur through E2 mechanism? [closed]

I have seen examples of dehydrohalogenation reaction that occur through E2 mechanism but never came across dehalogenation reaction that occur through E2 mechanism (for example, dehalogenation of 1,2-...
Asher2211's user avatar
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3 votes
1 answer
160 views

Does elimination occur when bromonapthalene is reacted with sodium amide in potassium hydroxide?

What should be the product of this reaction? Some books show that an elimination reaction would happen since $\ce{NH2-}$ is a strong enough base to take away a hydrogen on a benzene ring and create a ...
Sharbel Damouni's user avatar
6 votes
1 answer
263 views

When does reaction of alcohol with alumina give an ether and when an alkene?

What is the main product when an excess of ethyl alcohol vapour is passed over heated alumina at 250 °C? I read that this reaction gives an ether (here, diethyl ether) at relatively lower temperature ...
Prajwal Tiwari's user avatar
1 vote
1 answer
172 views

Which of the given compound has the highest rate of dehydration?

I came across this question recently: For which compound acid catalyzed dehydration rate is highest? Now, they all are secondary alcohols so their dehydration should follow E1 mechanism and the ...
WhySee's user avatar
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0 answers
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Evaluating inductive effects in cyclic compounds

I was required to find the products on heating the hydroxide of; Now it's easy enough to find the answer; Hoffman elimination isn't going to happen from the methyl, and the n-propyl doesn't have $\...
harry's user avatar
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2 votes
2 answers
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On the relative ease of E2 dehydration

Concerning alcohol dehydration, I get that it's E1 in secondary and tertiary alcohols, that it's E2 in primary alcohols, and also why E1 reaction is easier for tertiary alcohols as compared to ...
harry's user avatar
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Confusion regarding dehydration of 1° alcohols

My lecturer told me that 2° and 3° alcohols prefer to dehydrate through E-1 mechanism. On the other hand, 1° alcohols tend to prefer the E-2 mechanism, which does not involve the formation of a ...
C_Lycoris's user avatar
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E1 or E2 Elimination? Which Elimination occurs first?

In this reaction scheme, two dehydrobrominations occur. A bulky base is used but both hydrogens are sterically hindered. How is it possible to determine, which one is removed first? Or is this an $E_1$...
Linus's user avatar
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Decarboxylation of 2‐cyano‐2‐cyclohexylideneacetic acid [closed]

2‐Cyano‐2‐cyclohexylideneacetic acid (1) is heated and $\ce{CO2}$ is lost: [ Why is this not formed? In other words, why do π-electrons move into the ring?
rdx's user avatar
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Which is more reactive in E1, benzyl or allyl

I'm don't know the english terminology for chemistry so sorry for probably butchering some terms. My question is, which of these is more reactive in an E1 reaction: The bottom two are the ...
Daan Seuntjens's user avatar
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697 views

Elimination vs reduction reactions - how to tell

Here are two compounds: Compound H: and compound I: Compound H reactions with the reagent shown below to form compound I and two other products. How would you clarify this reaction? I thought it was ...
vgupt's user avatar
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2 votes
1 answer
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Equilibrium with an E2 step

E2 mechanisms are known to be irreversible in general, because the forward step takes 2 species and produces three species, and a trimolecular reverse step is unlikely, purely on entropic grounds. (As ...
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Major product in dehydration of alcohol

Consider the dehydration of the following molecule with conc. $\ce{H2SO4}$ at $443 \text K$: The possible products are: The first one is the Zaitsev product and the second one Hofmann product. ...
newbie105's user avatar
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Reaction of cyclohexene oxide with LDA

The question given above appeared in the 2016 Indian National Chemistry Olympiad (INChO). What I think is that the epoxide ring is being opened by a base-catalysed mechanism ($\mathrm{S_N2}$). I ...
Shishir Maharana's user avatar
1 vote
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Dehalogenation of vicinal dihalo alkanes

Which mechanism will the following reaction follow? Will it follow E2 mechanism? If yes, then how would 2,3-dibromobutane undergo this reaction? Does it form both cis and trans butene or is the ...
Desai's user avatar
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2 votes
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How to determine if a base is bulky?

I remember my teacher saying that during E2 (elimination bimolecular) reactions of alkanes, if the strong base that is used as a reagent is a bulky one, it has higher probability of giving a Hofmann (...
Desai's user avatar
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Which mechanism would be followed by a certain reaction with good leaving group?

In my class test, I was asked this question: Which mechanism would be followed by a certain reaction with good leaving group? E1 reaction E2 reaction No reaction both E1 and E2 I answered 4 ...
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Determine mechanism: E1 vs. E2

I am asked to indicate what is the product of this reaction, and the mechanism by which it is formed: 3-Bromo-3-ethylpentane + sodium hydroxide in methanol, 50 ºC I identify it as an elimination ...
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Finkelstein reaction of vicinal dihalides

I recently came across the following in my OChem class: Ethylene dichloride on reaction with NaI in acetone reacts via E2 mechanism to give ethene. I have three questions: Since it is an E2 ...
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Find the major products when these cyclohexenone bromides react with caustic potash in alcoholic medium:

Question: Also find the order of the rates of the given reactions. Answer: The answer of this question is given as option 'D' ie. all products are identical, however I am getting the answer as ...
Shriom707's user avatar
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How is elimination reaction (E1) possible without base and in presence of acid?

When learning about E1 we were taught that three things are important factors to judge if the reaction is E1 or E2 Substrate ( 3,2,1 favours E2 but only 3 favours E1 ) Base ( Stronger Base favours E2 ...
soutrik das's user avatar
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Phenethylhydrazone decomposition mechanism

I was going through a problem in the book Advanced problems in organic chemistry by Chouhan: I figured out that since di-isopropyl amide will act as a hindered base it will take out the following ...
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