Questions tagged [drugs]

Drugs or pharmaceuticals are substances or combinations used to diagnose, cure, treat, or prevent disease.

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Odd color reaction with Marquis and MDMA

The textbook colour reaction of Marquis reagent (mixture cc. $\ce{H2SO4}$ + formaldehyde, optionally with some methanol to slow down polymerization) with MDMA (3,4-methylenedioxy-methamphetamine, the ...
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1answer
368 views

What is the reaction mechanism for the hydrolysis of Amifostine?

I have to do research on a drug called Amifostine: 2-(3-aminopropylamino)ethylsulfanyl phosphonic acid. I'm supposed to say how the organic reaction works inside the body. I understand that it ...
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1answer
382 views

What general uses do beta-lactam functional groups have?

I am currently working on a mechanistic study that deals with stereoselective $\beta$-lactam formation. I am well aware that there is a class of antibiotics, that involve this particular functional ...
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2answers
188 views

How would one express pemoline in terms of phenethylamine?

Pemoline is a psychostimulant that is no longer used in most countries. Similarly to the psychostimulants amfetamine and methylphenidate I can clearly see a phenethylamine backbone to this compound. I ...
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1answer
40 views

Detecting the concentration of chlorpromazine

Is there a way to detect the concentration of chlorpromazine in a small sample ; ex: human saliva, using electro-chemical analysis? Does the sensor necessarily have to be a bulky piece of lab ...
3
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1answer
193 views

Does hydroxytyrosol have the same neurotoxicity potential as dopamine?

It has the catechol group, and it's the oxidation of the catechol group that makes dopamine produce reactive oxygen species (ROS). Hydroxytyrosol isn't that different from dopamine (the distal N ...
1
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1answer
658 views

Why does lactulose turn dark?

Why does the standard 10gm/15ml lactulose solution turn dark when exposed to heat above 30 degrees Celsius? This is probably a simple question. It is funny that the warnings/important information on ...
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1answer
446 views

How to Experimentally Quantify the Response of a Receptor to a Ligand?

In medicinal chemistry, there are multiple reasons why one would want to experimentally determine the effect of a particular molecule on a receptor e.g. measuring how 'strongly' that molecule brings ...
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1answer
151 views

Psychoactive ingredients in this soap?

Could any ingredients from this product be psychoactive in some people, if the are sensitive to them? https://www.lush.co.uk/products/honey-i-washed-kids I have found the product to be relaxing as ...
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2answers
738 views

What is the active ingredient in this “stimulant?”

It is an easily defensible argument that this is a medical question rather than a chemistry one, however, I feel that it leans ever so slightly towards chemistry, and so I posted it here. There is a "...
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0answers
183 views

How much hydrolysis will likely occur of the following bonds at pH 1-4 in the time period of 1-3 hours?

The bonds are: (I have given pictures of what I mean in case there's any ambiguity that I leave open in these questions. Also so that if you want to number the R groups you've got a head-start) ...
3
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2answers
1k views

Why do pharmaceutical drugs have a expiration date?

Every now and then you reach into the bathroom cabinet to find that some pill or ointment you where planning to use has gone past its expiration date. I am interested whether this expiration date has ...
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1answer
80 views

What compounds do Nor1 and Nor2 citalopram refer to?

In Goodman and Gilman's The Pharmacological Basis of Therapeutics 12th Edition pg. 406, two drugs, nor1-citalopram and nor2-citalopram are referred to but I have no idea what they are. Could somebody ...
5
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1answer
145 views

In Goodman and Gilman what does R,S-citalopram refer to?

In Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e R,S-citalopram is referred to. The problem is that from what I am aware of citalopram only has one stereocentre, and hence I am ...