Questions tagged [drugs]

Drugs or pharmaceuticals are substances or combinations used to diagnose, cure, treat, or prevent disease.

17 questions with no upvoted or accepted answers
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Is there a structured data source containing information on the World Health Organisation's Stability Testing Policies?

Hoping to automate some product testing guidance software, I've been attempting to find a (hopefully live, up-to-date) Database, Web-service, or other structured data source containing the ...
4
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2answers
187 views

Is there a potentiometric method for monitoring salt formation in organic solvent?

I work in a pharmaceutical R+D lab, and currently aim to develop a validatable potentiometric method for determining the optimal amount of acid to add to a basified small organic molecule for ...
4
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0answers
518 views

degradation of sertraline

The picture above is a drug called Setraline. Suggest a likely mode of degradation of sertraline hydrochloride alone in aqueous solution, giving likely structures of the degradation products. From my ...
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0answers
275 views

Combining amphetamine and MAOIs

Could combining amphetamine and a (possibly selective) MAOI (MonoAmine Oxidase Inhibitor) increase the amphetamines potency without serious toxic side effects? If so by what factor, and would this be ...
3
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0answers
1k views

What are the specific disadvantages of using a bio-catalyst (called Lipolase) in the synthesis of the drug pregabalin?

I am studying the synthesis of a drug pregabalin, for which both chemical and bio-catalysts are used. Using a biocatalyst is way better than chemical route, as explained here. In fact, The invention ...
3
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0answers
186 views

How much hydrolysis will likely occur of the following bonds at pH 1-4 in the time period of 1-3 hours?

The bonds are: (I have given pictures of what I mean in case there's any ambiguity that I leave open in these questions. Also so that if you want to number the R groups you've got a head-start) ...
2
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0answers
20 views

Chemical interaction between Pterostilbene and Nicotinamide Riboside

Some supplement companies are putting a combinations of nicotinamide riboside and pterostilbene into the same capsule. Considering the stomach acid, water, body temperature, etc. I am wondering if ...
2
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0answers
22 views

Cleaning of chlorbutyl plungers

This is my first post, so please bear with me. At work I have some chlorobutyl plungers that I need to clean from any residual material that might be left after production. A colleague of mine told ...
2
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0answers
174 views

What is the most likely reaction between minocycline and tramadol in physiological conditions?

Minocyline (left) and Tramadol (right) are two commonly prescribed medications containing typical organic functional groups. What would an expert chemist surmise as the first or most-likely reaction ...
2
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0answers
1k views

Odd color reaction with Marquis and MDMA

The textbook colour reaction of Marquis reagent (mixture cc. $\ce{H2SO4}$ + formaldehyde, optionally with some methanol to slow down polymerization) with MDMA (3,4-methylenedioxy-methamphetamine, the ...
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523 views

What is LSD-1, …, LSD-24, LSD-26, …?

LSD (lysergic acid diethylamide) was formerly often referred to as ‘LSD-25’. If it really is a (Albert Hofmann / Sandoz)'s code name (and not a combination of ‘LSD’ and usual LSD (Delysid) dosage ...
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40 views

How to characterise lipophilicity?

I was provided with a drug compound which is filling a hydrophobic pocket. The R group is changed and effects on the potency was measured; $\ce{R = -H, -CH3, -CH2F}$ were tested. As expected, the more ...
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0answers
57 views

How to find all published Pharmacophore Structure of a Drug target?

Other than literature review how do you find the structures of Pharmacophore of a drug target? I am searching Pyruvate Dehydrogenase Kinase (PDK) inhibitors and I have reviewed lots of literature but ...
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197 views

Absorption of Diazepam/Valium

Why diazepam absorbs quickly when taken with metoclopramide? Does it because diazepam is absorbed from intestine like acetaminophen? If it does, why presence of food increases the absorption of ...
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0answers
74 views

Microscale Experimentation vs. Preparative Synthesis during drug development

I'm trying to understand the drug development stages, techniques and procedures. My understanding on the subject: Microscale experimentation Is used on early stages to find compounds reacting with ...
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0answers
21 views

Understanding Overage in Tablet coating process

I understand that overage is included in preparation of tablets to account for losses in the delivery lines. But how do I apply them into calculations ? For example, I am trying to find out the amount ...
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14 views

(API) Assay & (API) Content Uniformity on tablets weight in pharmaceutical processes

From what know, Both assay and content uniformity are directly proportional to tablet weight. I want to know what’s the difference in these two different forms of API testing in tablets. I only know ...