Questions tagged [drugs]

Drugs or pharmaceuticals are substances or combinations used to diagnose, cure, treat, or prevent disease.

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36 views

How accurate is the drug manual provided with an injectable drug?

I was recently looking at how long can Remdesivir be stored in its different forms. I came up across several articles provided by the FDA and Gilead Sciences and others. What caught my eye was the ...
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1answer
25 views

Carbon 11 radiolabeled inhaled Beta-2 agonist or corticosteroids, is it possible?

Background Positron emission tomography (PET) is a highly sensitive imaging modality that can provide in vivo quantitative information of biological processes at a biochemical level. PET relies upon ...
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24 views

About the acidity of Sultiame [closed]

Why is sulthiam base even hough sulfur can accept the electron by resonance from nitrogen like carbonyl group do?
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1answer
3k views

Why is heroin a more potent drug than morphine, despite having a similar structure?

The structures of heroin and morphine are quite similar, with heroin being formed by acetylation of morphine: Why is heroin so much more potent than morphine, when their structures are so similar? ...
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2answers
224 views

Is there a potentiometric method for monitoring salt formation in organic solvent?

I work in a pharmaceutical R+D lab, and currently aim to develop a validatable potentiometric method for determining the optimal amount of acid to add to a basified small organic molecule for ...
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0answers
23 views

What computational software is available to simulate drug receptor activity?

Is there any programming software/simulation software that can allow us to see whether a drug/molecule can form interactions with a receptor/enzyme pocket. Does it have anything to do with molecular ...
8
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2answers
219 views

Why are drugs mixed with their sodium salts?

I have come across quite a few drugs that are of the form $\ce{HA + NaA}$, where $\ce{A}$ is your target organic compound. A few examples of this are: Carmicide which is a mixture of Sodium Citrate ...
2
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1answer
26 views

API formulations - are excipients required

I have the following API's Itraconazole, Ivermectin, Fenofibrate, Pyrvinium Pamoate,  Sulfasalazine, Artesunate,  All-Trans Retinoic Acid, Doxycycline,  Atovaquone,  Extremestane, Syrosingopine and ...
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3answers
10k views

What does it mean for meth or any other compound to be 'pure'?

In Breaking Bad, Walter White can cook $99.1\%$ pure meth. In general what does it mean for a substance to be pure? In this case, what exactly does it mean for meth to be pure? Does higher purity mean ...
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1answer
61 views

How does Combinatorial Chemistry differ from Rational Drug Design?

I stumbled on Vertex Pharmaceuticals - Wikipedia. It was one of the first biotech firms to use an explicit strategy of rational drug design rather than combinatorial chemistry. Then I looked up ...
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2answers
96 views

Are ethyl iodophenylundecylate and Ethyl-10-(Iodophenylundecanoate) the same compound?

I have no understanding of chemistry, so these to chemical formulas mean nothing to me. What I am trying to ascertain is are these compounds the same? If not, what differences are there especially if ...
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19 views

What is the composition, function, and classification of “6-Thio-2-Deoxyguanosine” and “13-mer thio-phosphoramidate”? How do I learn more about them?

I am assigned the task of explaining a biomedical research paper, it is about telomere and telomerase , and it talks a lot about the molecule Thio-2-Deoxyguanosine , 13-mer thio-phosphoramidate and &...
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3answers
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What is the difference between doxycycline HCl and doxycycline hyclate?

I would like to ask what are the main differences between doxycycline HCl and hyclate? I work in the pharmaceutical/veterinary raw materials industry and some clients are saying that they prefer ...
27
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2answers
3k views

The importance of the cold chain in the food and the pharmaceutical industry

There are these everyday things that one should know as a scientist and especially as a chemist, but which never come to light in an academic curriculum — at least not in mine. One such thing is the ...
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1answer
602 views

Number of chiral centers in penicillin V

I have often seen that in many drugs chirality plays a role. So I was trying to analyze the structure of Penicillin V. What is number of chiral centers in the structure of penicillin V? Is the ...
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1answer
39 views

Synthesis cost of Fomepizole

Fomepizole is essential drug for methanol poisoning, I observed it cost too much like in 1000's of dollar for couple of ml. Is cost due to patents, or due to synthesis cost,structure of molecule looks ...
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2answers
1k views

What is LSD-1, …, LSD-24, LSD-26, …?

LSD (lysergic acid diethylamide) was formerly often referred to as ‘LSD-25’. If it really is a (Albert Hofmann / Sandoz)'s code name (and not a combination of ‘LSD’ and usual LSD (Delysid) dosage ...
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0answers
36 views

Does HI-6 form a covalent adduct with acetylcholinesterase?

According to sources provided below, the oxime HI-6, or Asoxime Dichloride, as it is also called, besides being a reactivator of acetylcholinesterase that has been inhibited by organophosphorus ...
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0answers
33 views

A dataset of drugs or molecules that failed the FDA approval process

I am looking for a dataset of bad drugs, the opposite of FDA approved drugs. There is this database of withdrawn drugs, but these drugs were withdrawn after making it into the market. Is there any ...
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0answers
38 views

Definition of throughput

I wonder what's the exact meaning of throughput in chemistry synthesis, eg. in organic synthesis or production of pharmaceutical products. For instance, what are their units? How are they measured? I'...
3
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0answers
64 views

How to make Lithium medication from scratch

I take lithium carbonate as a medication. I was watching an "apocalypse-style" movie recently, which made me wonder how hard it would be to make my medication from scratch if I could no ...
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1answer
74 views

Meaning of “MS1 and MS2 resolution” and “MS1 and MS2: Unit” in a tandem mass-spectrometry parameter list

I'm translating a Certificate of Suitability that very briefly describes procedures used to measure several impurities in a drug substance. There is a short description of the parameters of a Gas ...
2
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1answer
909 views

Why does lactulose turn dark?

Why does the standard 10gm/15ml lactulose solution turn dark when exposed to heat above 30 degrees Celsius? This is probably a simple question. It is funny that the warnings/important information on ...
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1answer
537 views

When can you use the direct flame of a Bunsen burner, and when must you boil a beaker of water first?

I'd like to ask when you would do the following: use the direct Bunsen flame to heat a substance; place the substance in a test tube, which is placed in a beaker of water, then boil the water with the ...
4
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1answer
427 views

What is the reaction mechanism for the hydrolysis of Amifostine?

I have to do research on a drug called Amifostine: 2-(3-aminopropylamino)ethylsulfanyl phosphonic acid. I'm supposed to say how the organic reaction works inside the body. I understand that it's ...
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1answer
51 views

can you explain the structure of gemtuzumab ozogamicin? where are the linker boundaries?

could someone help me to decipher the structure of this molecule? I am trying to understand the structure of gemtuzumab ozogamicin: The anti-CD33 antibody is acylated with the bifunctional AcBut ...
3
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0answers
43 views

Bioinformatics tools for predicting synthetic reaction for identified drugs?

We are aware of many bioinformatics open source tools like AUTODOCK, Smina for drug discovery through structure based virtual screening. I was wondering if there are validated bioinformatics tools ...
5
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0answers
163 views

Interference of Ca-EDTA with fluoride delivery in mouthwash

The goal of fluoride mouthwash is to deliver $\ce{F-}$ to the surface of the teeth to turn hydroxyapatite in the dental enamel into fluorapatite. Typically sodium fluoride or stannous fluoride are ...
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1answer
498 views

Wouldn't a better term for smoking Crystal meth be condensing or vaporizing?

There isn't actually any chemical reaction taking place. The meth is heated, first it melts, then it vaporizes, but in the process it doesn't mix with other chemicals. It just merely changes state. ...
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1answer
175 views

Do we get high on “methampetamine” naturally? [closed]

First off, I'm new here and I cant tell if this is a chemistry or a biology question. It's both and if I ask on biology forums, they say to ask on chemistry forums and vice versa. So sorry if this ...
3
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1answer
2k views

Crystal meth in Breaking Bad [closed]

Can good quality crystal meth really be made as in Breaking Bad? Can a pharmaceutical drug really be reverse-engineered?
9
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525 views

Synthetic route to hydroxychloroquine

This drug hydroxychloroquine has become a new burning topic of discussion as a chemistry enthusiast: I know that in an industrial preparation we need to account fpr a lot of factors like temperature, ...
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2answers
59 views

How to publish a review article on drugs in a reputed journal? [closed]

What are the things needed to publish a review article in a journal starting from scratch ? Is it possible if i am not associated to any institution ? How long does it take and what are all the ...
2
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0answers
47 views

Difference between docking and scoring?

I'm taking an undergraduate level class on computer based drug design. The class is more for biology students than people with a strong understanding in physics and computer science. With that said,...
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1answer
56 views

Drug design methods - docking software, binding affinity [closed]

Lately I've seen videos and some articles explaining drug design. I would also like to specifically cite this guy, who isn't the most credible guy in the planet, but some of the stuff in the video ...
1
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1answer
78 views

How does gefitinib affect the EGFR(ecptor) and why is there relapse

Gefitinib has been shown to be an effective tyrosine kinase inhibitor in a fraction (~$10$%) of non-small cell lung cancer patients. These patients are characterized as having a mutation (usually a ...
2
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0answers
51 views

Do any pharmaceuticals increase in potency or toxicity over time?

Pursuing a question raised in these comments: Are there any known pharmaceuticals that increase in potency or toxicity during storage, or over periods of months to years? If not, what if we broaden ...
1
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1answer
43 views

Estimating protein binding and disassociation

I don't have a background in the area of drugs or pharmacokinetics/Pharmacodynamics but I am trying to understand about protein binding. I was going through this paper. If $C_b$ is the ...
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1answer
83 views

Conversion of barbituric acid to veronal

This is just out of curiosity. I have no intention or authority to do conversions. I am studying chemistry of tranquilizers, in that an important class is of barbiturates, which are also hypnotics. ...
14
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1answer
2k views

What was the lithium concentration in 1940's 7-Up?

I just came across this article in the New York Times, where lithium (or more correctly, lithium salts), a known anti-depressant had been added to beverages in the 1940's. They also mention that a ...
13
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2answers
2k views

Effect of enatiomers in pharmaceuticals [closed]

Often (or always?) one enantiomer of a certain drug will be effective and the other ineffective or harmful. The famous example is thalidomide, where one enantiomer caused mutilation of the unborn ...
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0answers
32 views

Racemic mixture vs enantiomers in drugs [duplicate]

a racemic mixture has 50-50% of the 2 different enantiomers. There are racemate drugs out there in the world. The misunderstanding I have is that usually 1 out of the 2 enantiomers molecules have a ...
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1answer
3k views

What is the chemical equation for penicillin? [closed]

For our chemistry homework, we have to write the chemical equation for Penicillin.
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23 views

Chemical interaction between Pterostilbene and Nicotinamide Riboside

Some supplement companies are putting a combinations of nicotinamide riboside and pterostilbene into the same capsule. Considering the stomach acid, water, body temperature, etc. I am wondering if ...
6
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1answer
3k views

Which poison was used in the failed attempt to assassinate Khaled Mashal of Hamas?

This question is both historical and chemistry-related, but I'm posting it here because I am more interested in the chemical part: In 1997, Israel tried to assassinate Khaled Mashal, a high-rank ...
2
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0answers
23 views

Cleaning of chlorbutyl plungers

This is my first post, so please bear with me. At work I have some chlorobutyl plungers that I need to clean from any residual material that might be left after production. A colleague of mine told ...
7
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1answer
125 views

Preparation of Effexor

I take venlafaxine (Effexor) as medication, and having wrapped up 2 semesters of Organic Chemistry I thought it might be fun to design a synthesis for it. A picture of venlafaxine: I came up with the ...
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1answer
390 views

Is scopolamine same as scopolamine hydrobromide?

Is scopolamine extracted with methanol or acetone from Datura or Brugmansia scopolamine free base or scopolamine hydrobromide? If you take a look at the Wikipedia page for hyoscine, the Synonyms part ...
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1answer
111 views

What chemicals are in anesthetic drugs [closed]

What chemicals are there in an anesthetic drug and how it reduces the pain of a person? Are the chemicals used in it safely, dangerous or both?
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84 views

Is there a structured data source containing information on the World Health Organisation's Stability Testing Policies?

Hoping to automate some product testing guidance software, I've been attempting to find a (hopefully live, up-to-date) Database, Web-service, or other structured data source containing the ...