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Questions tagged [drugs]

Drugs or pharmaceuticals are substances or combinations used to diagnose, cure, treat, or prevent disease.

3
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2answers
169 views

Is there a potentiometric method for monitoring salt formation in organic solvent?

I work in a pharmaceutical R+D lab, and currently aim to develop a validatable potentiometric method for determining the optimal amount of acid to add to a basified small organic molecule for ...
2
votes
2answers
62 views

Why would diclofenac have a higher skin permeability when formulated as diclofenac epolamine rather than diclofenac sodium?

There is a suggestion on the literature that the formation of ion pairs creates a permeation enhancement. Usually only non-ionised compounds penetrate the skin. Is it possible that the conjugate ...
1
vote
1answer
277 views

In the graph provided, which of the substances is the most efficient in acting as an antacid?

If every dot represents the addition of 0.1 g of the respective base. I suppose that the best would be the one that reaches the highest pH, in the shortest time, for example Calcium Carbonate, but if ...
13
votes
0answers
353 views

What was the lithium concentration in 1940's 7-Up?

I just came across this article in the New York Times, where lithium (or more correctly, lithium salts), a known anti-depressant had been added to beverages in the 1940's. They also mention that a ...
10
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0answers
63 views

Is there a structured data source containing information on the World Health Organisation's Stability Testing Policies?

Hoping to automate some product testing guidance software, I've been attempting to find a (hopefully live, up-to-date) Database, Web-service, or other structured data source containing the ...
4
votes
0answers
453 views

degradation of sertraline

The picture above is a drug called Setraline. Suggest a likely mode of degradation of sertraline hydrochloride alone in aqueous solution, giving likely structures of the degradation products. From my ...
3
votes
0answers
214 views

Combining amphetamine and MAOIs

Could combining amphetamine and a (possibly selective) MAOI (MonoAmine Oxidase Inhibitor) increase the amphetamines potency without serious toxic side effects? If so by what factor, and would this be ...
3
votes
0answers
1k views

What are the specific disadvantages of using a bio-catalyst (called Lipolase) in the synthesis of the drug pregabalin?

I am studying the synthesis of a drug pregabalin, for which both chemical and bio-catalysts are used. Using a biocatalyst is way better than chemical route, as explained here. In fact, The invention ...
3
votes
0answers
180 views

How much hydrolysis will likely occur of the following bonds at pH 1-4 in the time period of 1-3 hours?

The bonds are: (I have given pictures of what I mean in case there's any ambiguity that I leave open in these questions. Also so that if you want to number the R groups you've got a head-start) ...
2
votes
0answers
128 views

What is the most likely reaction between minocycline and tramadol in physiological conditions?

Minocyline (left) and Tramadol (right) are two commonly prescribed medications containing typical organic functional groups. What would an expert chemist surmise as the first or most-likely reaction ...
2
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0answers
1k views

Odd color reaction with Marquis and MDMA

The textbook colour reaction of Marquis reagent (mixture cc. $\ce{H2SO4}$ + formaldehyde, optionally with some methanol to slow down polymerization) with MDMA (3,4-methylenedioxy-methamphetamine, the ...
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vote
0answers
131 views

What is LSD-1, …, LSD-24, LSD-26, …?

LSD (lysergic acid diethylamide) was formerly often referred to as ‘LSD-25’. If it really is a (Albert Hofmann / Sandoz)'s code name (and not a combination of ‘LSD’ and usual LSD (Delysid) dosage ...
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0answers
33 views

How to characterise lipophilicity?

I was provided with a drug compound which is filling a hydrophobic pocket. The R group is changed and effects on the potency was measured; $\ce{R = -H, -CH3, -CH2F}$ were tested. As expected, the more ...
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0answers
52 views

How to find all published Pharmacophore Structure of a Drug target?

Other than literature review how do you find the structures of Pharmacophore of a drug target? I am searching Pyruvate Dehydrogenase Kinase (PDK) inhibitors and I have reviewed lots of literature but ...
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0answers
162 views

Absorption of Diazepam/Valium

Why diazepam absorbs quickly when taken with metoclopramide? Does it because diazepam is absorbed from intestine like acetaminophen? If it does, why presence of food increases the absorption of ...
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0answers
59 views

Microscale Experimentation vs. Preparative Synthesis during drug development

I'm trying to understand the drug development stages, techniques and procedures. My understanding on the subject: Microscale experimentation Is used on early stages to find compounds reacting with ...