Questions tagged [acylation]

Acylation is the process of adding an acyl group to a compound.

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How many times does substitution happen here?

(This question is from a dubious source) The reaction taking place here is Friedel-Crafts acylation of benzene with 1-chloro 2,2-dimethyl propanone (pivaloyl chloride?). To me, the options seem most ...
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Reaction of methyl triphenylbenzoate with concentrated sulphuric acid

In the following reaction, compound Q is obtained from compound P via an ionic intermediate. What is the degree of unsaturation of Q? This question was asked in JEE ADV 2020 I thought that the ester ...
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Why is the dipole moment of Anisole less than that of Phenol? [closed]

According to Wikidata, anisole has a dipole moment of 1.38D and according to this page on Researchgate, phenol has a dipole moment of 1.70D. Resonance in anisole: Resonance in phenol: According to my ...
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Is RCOOH + H2SO4 + heat a viable alternative to RCOCl + AlCl3 in Friedel-Crafts acylation?

Can concentrated strong acid like H₂SO₄ be used to protonate a carboxylic acid to RC(OH)₂⁺, forming RCO⁺ by removal of H₂O, analogous to the reaction with nitric acid to produce nitronium? Would this ...
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Friedel-Crafts acylation with withdrawing group?

Will a Friedel- Crafts acylation take place on ortho-bromotoluene? I do understand that Friedel Crafts reaction does not occur when there is an electron withdrawing group on the ring but is there any ...
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Multi-step organic synthesis using benzene [closed]

I have this project that I've been struggling with. I'm already given the reactant and product, so basically what I have to do is to figure out the steps needed to get the product. I figured that ...
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Reaction/complexation of aluminium chloride and acetic acid

Thinking about Friedel-Crafts acylation using carboxylic acid anhydride got me wondering about how exactly aluminium chloride ends up in that reaction. Generally, despite the fact that Friedel-Crafts ...
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Lactone acylation

Can anyone propose/draw a mechanism for Method A, below, from this paper? Almost all other literature use method B and reagents such as SOCl2.
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Synthesis of synthetic detergent with Friedel Crafts Acylation

I propose the following synthesis. Oxidation of aldehyde to a carboxylic acid. This sets me up for FC acylation once I ... Attack the -OH with thionyl chloride ad form the acid chloride. Reaction ...
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