# Is every compound that has a H-bond donating group soluble in water? [closed]

I am wondering if there is any general rule of thumb

## closed as off-topic by A.K., Tyberius, a-cyclohexane-molecule, Gaurang Tandon, MithoronJul 19 '18 at 14:31

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• There are hardly any such simple generalisations that can be made in chemistry for the solubility of compounds. If the compound has a large nonpolar domain, clearly it won't be water soluble despite having an -OH group. – Tan Yong Boon Jul 19 '18 at 1:44
• If we are making generalisations, I would say they are harmful. ;-) – Karl Jul 19 '18 at 5:20

Definitely not. For instance, palmitic acid with a pK$_\mathrm{a}$ of 4.75 has a water solubility of only 0.04 mg/L.