1
$\begingroup$

In a six membered lactone with carbaldehyde in beta position, which oxygen gets protonated first? the lactone or the aldehyde? (Using concentrated HCl)

2-oxooxane-4-carbaldehyde

$\endgroup$
  • 2
    $\begingroup$ You should assume both will be protonated and deprotonated reasonably quickly. If you're trying to get good selectivity between the two, you're out of luck. $\endgroup$ – Zhe May 7 '18 at 13:53

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.