I want to produce alginate nanoparticles from NaAlg. I choosed nebulizing NaAlg solution into $\ce{CaCl2}$ solution but 2% (m/v) NaAlg solution is quite viscous. What should I do to make it inviscid?


Dilute the feed solution tenfold, etc. Inelegant. Try solution engineering,

Chaotropes and kosmotropes.

Add a little "poor" solvent like ethanol or acetone to ball the polymer, disrupting hydrogen bond crosslinking and reducing chain entanglement.

You want a novel solution not obvious to one skilled in the art. That qualifies it for patent protection. A large fraction of the hard answers you need already exist. They were done by other people doing other things. Accumulate bone piles of knowledge. The process for creating ceramic dislocation-pinned nickel superalloys works for Plexiglass, which "dissolves" 30 wt-% copper phthalocyanine as a dye masterbatch. So it can't be done, so what? Do it the "other" way.


Heating most viscous solution will decrease their viscosity. Most agar gels will liquefy when heated. Also, some polysaccharide solutions don't become viscous again when they cool down. I think alginate will become viscous, but you will have to test that out.


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