Does anyone know of a resource which clearly explains the scientific theory and experimental methods involved in chiral resolutions?

I have access to the American Chemical Society, Tetrahedron, Royal Society of Chemistry and many other journals and books.

I am an undergraduate student doing laboratory research. I am about to separate enantiomers, which are atropisomers. I am looking for something that I can understand with my limited experience, as I have only taken two semesters of undergraduate organic chemistry. Also, maybe something brief since I will have to do the resolutions in only a few weeks, but that is less important.

  • 1
    $\begingroup$ Unfortunately, separation of enantiomers is not a generally solved problem. It depends very heavily on the functional groups in your substrate. If you're only looking to separate a small amount, I'd recommend chiral prep HPLC. $\endgroup$
    – Zhe
    Mar 2, 2018 at 16:39
  • 1
    $\begingroup$ I would try and find the book Enantiomers, Racemates and Resolutions by Jacques, Collet and Wilen $\endgroup$
    – Beerhunter
    Mar 2, 2018 at 22:48


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