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In this reaction, what are the ideal circumstances? ttt

  1. Which base would be a great choice?
  2. How much time does it take for tryptophan to fully decarboxylate?
  3. What is the ideal temperature for this type of reaction?
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closed as too broad by Mithoron, a-cyclohexane-molecule, andselisk, Tyberius, airhuff Jan 18 '18 at 19:41

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Just heating with base is ineffective. Synlett 2003 542 describes a general procedure for the decarboxylation of alpha-amino acids using N-bromosuccinimide and Ni(0) in aqueous soln. The yields are pretty good.

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  • $\begingroup$ Thank you, btw heating with base why doesn't effective? What would happen to tryptophan? $\endgroup$ – ostal123 Jan 18 '18 at 13:21
  • $\begingroup$ I think you would just get a very hot soln of the sodium salt of tryptophan. $\endgroup$ – Waylander Jan 18 '18 at 14:06

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