-1
$\begingroup$

In this reaction, what are the ideal circumstances? ttt

  1. Which base would be a great choice?
  2. How much time does it take for tryptophan to fully decarboxylate?
  3. What is the ideal temperature for this type of reaction?
$\endgroup$
3
$\begingroup$

Just heating with base is ineffective. Synlett 2003 542 describes a general procedure for the decarboxylation of alpha-amino acids using N-bromosuccinimide and Ni(0) in aqueous soln. The yields are pretty good.

$\endgroup$
  • $\begingroup$ Thank you, btw heating with base why doesn't effective? What would happen to tryptophan? $\endgroup$ – ostal123 Jan 18 '18 at 13:21
  • $\begingroup$ I think you would just get a very hot soln of the sodium salt of tryptophan. $\endgroup$ – Waylander Jan 18 '18 at 14:06

Not the answer you're looking for? Browse other questions tagged or ask your own question.