- Which base would be a great choice?
- How much time does it take for tryptophan to fully decarboxylate?
- What is the ideal temperature for this type of reaction?
closed as too broad by Mithoron, a-cyclohexane-molecule, andselisk♦, Tyberius, airhuff Jan 18 '18 at 19:41
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Just heating with base is ineffective. Synlett 2003 542 describes a general procedure for the decarboxylation of alpha-amino acids using N-bromosuccinimide and Ni(0) in aqueous soln. The yields are pretty good.