In this reaction, what are the ideal circumstances? ttt

  1. Which base would be a great choice?
  2. How much time does it take for tryptophan to fully decarboxylate?
  3. What is the ideal temperature for this type of reaction?

Just heating with base is ineffective. Synlett 2003 542 describes a general procedure for the decarboxylation of alpha-amino acids using N-bromosuccinimide and Ni(0) in aqueous soln. The yields are pretty good.

  • $\begingroup$ Thank you, btw heating with base why doesn't effective? What would happen to tryptophan? $\endgroup$ – ostal123 Jan 18 '18 at 13:21
  • $\begingroup$ I think you would just get a very hot soln of the sodium salt of tryptophan. $\endgroup$ – Waylander Jan 18 '18 at 14:06

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