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While working with chiral molecule, we have pyridine in our reaction mixture. Molecule has four chiral centre and protection group-diacetal and acetyl groups which may break in harsh conditions. Please suggest work up methods to remove pyridine.

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  • $\begingroup$ Please, provide name/structure of the compound. As a general idea, I think pyridine might be evaporated given enough time, but it definitely is not fast or easy. $\endgroup$ – permeakra Oct 27 '17 at 6:26
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    $\begingroup$ Aquaeous extraction with a saturated ammonium chloride solution is usually the way to go. $\endgroup$ – Jan Oct 27 '17 at 8:05
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Extract the organic soln of the product with dilute aq. Cu(II) until the characteristic blue of the Cu-pyridine complex is absent from the aq. phase.

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