4
$\begingroup$

While working with chiral molecule, we have pyridine in our reaction mixture. Molecule has four chiral centre and protection group-diacetal and acetyl groups which may break in harsh conditions. Please suggest work up methods to remove pyridine.

$\endgroup$
  • $\begingroup$ Please, provide name/structure of the compound. As a general idea, I think pyridine might be evaporated given enough time, but it definitely is not fast or easy. $\endgroup$ – permeakra Oct 27 '17 at 6:26
  • 2
    $\begingroup$ Aquaeous extraction with a saturated ammonium chloride solution is usually the way to go. $\endgroup$ – Jan Oct 27 '17 at 8:05
5
$\begingroup$

Extract the organic soln of the product with dilute aq. Cu(II) until the characteristic blue of the Cu-pyridine complex is absent from the aq. phase.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.