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Rearrangements in Clemmensen reduction

What is the possible mechanism for this reaction? Activated zinc in presence of concentrated hydrochloric acid is used for Clemmensen reduction, that is conversion of ketone group to methylene group. I'd expect the product to be 1-methyl-2-propylpyrrolidine:

1-methyl-2-propylpyrrolidine

However, ring expansion occurs leading to a piperidine derivative. Could anyone please explain or provide a mechanism for the conversion? Thanks!

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Regarding this question, there are two things that should be stated beforehand.

Firstly, the mechanism of the Clemmensen reduction is not well-understood. There are two plausible pathways that have been proposed:1

Proposed mechanisms of Clemmensen reduction, from Kürti-Czakó

so, the mechanism for this rearrangement is equally unclear.

Secondly, this compound does not actually undergo rearrangement in the Clemmensen reduction, according to studies by Leonard and Ruyle.2 Curiously, the authors could only isolate the alcohol product. No explanation was offered as to why the alkane was not obtained.

Reduction of 1-methyl-2-propionylpyrrolidine


However, α-aminoketones are known to undergo rearrangement when the nitrogen and the carbonyl carbon are in the same ring. Two examples which Leonard and Ruyle studied are offered below:2,3

some rearrangements in the Clemmensen reduction

Their proposed mechanism occurs via migration of the C–N bond, following protonation of the carbonyl oxygen. The carbocation is captured by what appears to be hydride, although the existence of hydride is inconsistent with the proposed mechanisms we have seen above. It might just be their shorthand for sequential electron + proton transfer; I can't really tell.

mechanism, part 1

The second half of the mechanism is not explained, but it is plausible to protonate the hydroxyl group and use the nitrogen lone pair to expel water.

The authors posit that the tendency to undergo rearrangement here is related to a "geometrical directing effect": in the case where the nitrogen and the carbonyl carbon are in the same ring, the nitrogen lone pair has a larger opportunity to approach the carbonyl carbon.2 In modern-day terms, this might be considered to be a stereoelectronic effect.

How can this be reconciled with the proposed mechanisms in Kürti-Czakó? Considering that the mechanism of the reduction itself is unclear, I do not want to make any assertions about what the exact mechanism of this rearrangement is. However, I think it would be plausible that C–N bond migration can occur at some stage in the above mechanism - especially in the intermediates where the carbon bears a positive charge.


References

  1. Kürti, L.; Czakó, B. Strategic Applications of Named Reactions in Organic Synthesis; Elsevier: Amsterdam, 2005; p 92.

  2. Leonard, N. J.; Ruyle, W. V. Rearrangement of α-Aminoketones During Clemmensen Reduction. II. Contraction of a Six-membered Ring in the Monocyclic Series. J. Am. Chem. Soc. 1949, 71 (9), 3094–3098. DOI: 10.1021/ja01177a043.

  3. Leonard, N. J.; Wildman, W. C. Rearrangement of α-Aminoketones During Clemmensen Reduction. I. Bicyclic Compounds Containing a Bridge-head Nitrogen. J. Am. Chem. Soc. 1949, 71 (9), 3089–3093. DOI: 10.1021/ja01177a042.

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    $\begingroup$ Thanks! It's clear now. Just another thing, I also remember reading that 5,5-dimethylcyclohexane 1,3-dione on treatment with Zn-Hg in presence of HCl (Clemmensen reduction) gives 2,4,4-trimethylcyclopentanone. This is clearly an example of ring contraction. How does it occur? I'd like to know a mechanism for this conversion too. Also, as six membered rings are more stable than five membered rings, I'd predict that the reaction is not feasible, but it is. How? $\endgroup$ – arya_stark Sep 22 '17 at 9:51
  • $\begingroup$ @user28968, for your first question I'd suggest you ask a new question. Regarding the 6 vs 5 membered ring, you're making an implicit assumption that the reaction is thermodynamically controlled at some stage. I'm not sure if that is necessarily the case here. It is difficult to analyse it in any meaningful way, though, since the mechanism is not confirmed to begin with. $\endgroup$ – orthocresol Sep 22 '17 at 11:23
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Orthocresol is correct. The mechanism of the Clemmensen Reduction is enigmatic. Leonard and co-authors provided a 1949-type mechanism where hydride or zinc-nascent hydrogens was the reducing agents of the carbocation while not addressing the issue that the amine is totally protonated in conc. HCl (pKa H3O+ ~-1.7; pKa "NH4+" 9.3]. The nitrogen electron pair is not available as described by Leonard. Orthocresol has provided both prevailing options for the Clemmensen Reduction. I'll focus on the carbenoid route. Structures 2 are three ways of thinking

Clemmensen Mechanism

about a carbene for mechanistic purposes: metal bound 2a, electron pair 2b and vacant and filled orbitals 2c. Bond migration in 2c affords 3a, which is equivalent to a nitrogen protonated enamine 3b. However, enamines1,2 such as 1-pyrrolidino cyclohexene undergo facile hydrolysis in aqueous acid. This means that C-protonation occurs to give an immonium salt and, if N-protonation occurs, it is reversible. Given an N-protonated enamine here, isomerization to the immonium salt 4 is expected followed by a 2-electron reduction to afford the tertiary amine 5.

  1. In Memoriam: Professor Gilbert Stork (1921-2017)
  2. Stork, G., et al., J. Am. Chem. Soc., 1963, 85, 207. http://pubs.acs.org/doi/abs/10.1021/ja00885a021
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