0
$\begingroup$

I'm looking to make a thiourea from a monosubstituted urea. I haven't found any references that use Lawesson's Reagent, which I have been using for the thionation of di and trisubstituted ureas. Is there something that would prevent Lawesson's Reagent from working on a monosubstituted urea?

enter image description here

$\endgroup$
1
$\begingroup$

I believe Lawesson's Reagent could do this. It is useful to thionate a large number of carbonyl compounds including amides, so I think it can do for urea as well. I don't see any effect on a monosubstituted urea that would negatively affect the reaction.

Thionation of carbonyl compounds by Lawesson's Reagent

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.