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I'm looking to make a thiourea from a monosubstituted urea. I haven't found any references that use Lawesson's Reagent, which I have been using for the thionation of di and trisubstituted ureas. Is there something that would prevent Lawesson's Reagent from working on a monosubstituted urea?

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I believe Lawesson's Reagent could do this. It is useful to thionate a large number of carbonyl compounds including amides, so I think it can do for urea as well. I don't see any effect on a monosubstituted urea that would negatively affect the reaction.

Thionation of carbonyl compounds by Lawesson's Reagent

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