I know that CCSD(T) with the aug-cc-pVTZ basis set for geometry optimization of omeprazole (5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-benzimidazole, the active substance in Losec) is not suitable using normal computers. The substance is:
Can someone explain to me what exactly makes these methods too expensive for this substance?