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Minocyline (left) and Tramadol (right) are two commonly prescribed medications containing typical organic functional groups.

What would an expert chemist surmise as the first or most-likely reaction involving these drugs in the human body, if any? For example, in the stomach, in a highly acidic environment?

I realize the chemistry here is obviously complex, so an answer excluding biological components is fine. e.g. what would these compounds do in a solution of $\ce{HCl}$ alone?

I'm not an organic chemist, but my guess is that $\ce{HCl}$ can protonate an amine to encourage some kind of reaction.

In any case, some research has shown that the drugs may have a synergistic effect for pain relief: https://www.ncbi.nlm.nih.gov/pubmed/22964800.

Minocyline Tramadol

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  • $\begingroup$ You're looking for reactions between these two substances under physiological conditions? Or do you just want to know how they are individually metabolized? $\endgroup$ – Zhe Jul 7 '17 at 2:54
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    $\begingroup$ Reactions between. $\endgroup$ – khaverim Jul 7 '17 at 2:54
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    $\begingroup$ I would expect that you'd protonate the nitrogens and for ammonium ions. They don't quite have the best functional groups for cross reactivity... $\endgroup$ – Zhe Jul 7 '17 at 2:56
  • $\begingroup$ There's no reaction. If there was it would be used purposefully, or dangerous. $\endgroup$ – Mithoron Jul 7 '17 at 18:29

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