# What is the most likely reaction between minocycline and tramadol in physiological conditions?

Minocyline (left) and Tramadol (right) are two commonly prescribed medications containing typical organic functional groups.

What would an expert chemist surmise as the first or most-likely reaction involving these drugs in the human body, if any? For example, in the stomach, in a highly acidic environment?

I realize the chemistry here is obviously complex, so an answer excluding biological components is fine. e.g. what would these compounds do in a solution of $\ce{HCl}$ alone?

I'm not an organic chemist, but my guess is that $\ce{HCl}$ can protonate an amine to encourage some kind of reaction.

In any case, some research has shown that the drugs may have a synergistic effect for pain relief: https://www.ncbi.nlm.nih.gov/pubmed/22964800.

• You're looking for reactions between these two substances under physiological conditions? Or do you just want to know how they are individually metabolized? – Zhe Jul 7 '17 at 2:54
• Reactions between. – khaverim Jul 7 '17 at 2:54
• I would expect that you'd protonate the nitrogens and for ammonium ions. They don't quite have the best functional groups for cross reactivity... – Zhe Jul 7 '17 at 2:56
• There's no reaction. If there was it would be used purposefully, or dangerous. – Mithoron Jul 7 '17 at 18:29