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In a lecture about anabolic pathways of sugar, the lecturer was not clear when stating the name of a multiple sugar carrier & it sounded like "dolichol"so is it correct?

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  • $\begingroup$ en.wikipedia.org/wiki/Dolichol $\endgroup$
    – NotEvans.
    Jun 25, 2017 at 16:56
  • $\begingroup$ @xavier I'm not particularly looking forward to see this question tagged under biochemistry. The tag wiki (excerpt) clearly states that the tag ought to be used if the post is about biochemical processes ;P $\endgroup$ Jun 25, 2017 at 17:26
  • $\begingroup$ Apologies I was thinking of sugar transfer reactions in which dolichols take part in biochemistry, and I thought it was fitting $\endgroup$ Jun 25, 2017 at 17:28
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    $\begingroup$ I'm no biochemist, but... aren't the title of the the post (definition of a "sugar"), and the post itself (is there a certain something called "dolichol"?), two different things? o_o $\endgroup$ Jun 25, 2017 at 17:28
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    $\begingroup$ Maybe the title is slightly off, but I am sure OP is referring to anabolic pathways specifically sugar transfer reactions, in body text :) $\endgroup$ Jun 25, 2017 at 17:30

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Absolutely correct!

N-Linked oligosaccharides are initially synthesized as lipid-linked precursors. The lipid component in this process is dolichol, a long-chain polyisoprenol of 14 to 24 isoprene units (17–21 units in animals and 14–24 units in fungi and plants; isoprene units are C5 units with the carbon skeleton of isoprene , which is linked to the oligosaccharide precursor via a pyrophosphate bridge.

Dolichols apparently anchor the growing oligosaccharide to the endoplasmic reticulum membrane. These compounds have strong hydrophobic interactions with membrane lipids, anchoring the attached sugars to the membrane, where they participate in sugar-transfer reactions.

The pathway of dolichol-PP-oligosaccharide synthesis involves stepwise addition of monosaccharide units to the growing glycolipid by specific glycosyltransferases to form a common “core” structure:

enter image description here

Dolichol pyrophosphate glycoside. The carbohydrate precursors of N-linked glycosides are synthesized as dolichol pyrophosphate glycosides. Dolichols are longchain polyisoprenols (n = 14–24) in which the α-isoprene unit is saturated.

References

  • Voet and Voet Biochemistry

  • Lehninger Principles of Biochemistry

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