I need to maintain a certain range of % of ionisation from a buffer.
For e.g. Histidine buffer. When making high concentration of this buffer at (say) pH 7.2, 25'C, [concentration] is limited to 75mM solution (250mL), due to the solubility. Adding HCl increases solubility just as much, but it also decreases pH of the solution.
I want to know if there's a calculation or a formula to figure out the concentration limits (at least the highest concentration) of a particular buffer one can plan to make instead of trial and error in the lab?