# How do we know which compounds have higher solubility? [closed]

Is there any way we can look at the chemical formula of various compounds, do some calculations or something and figure out which compounds will have higher solubility as compared to the others.

• Your question needs more clarification. Are you really asking if you can predict solubility from the formula, or from the chemical structure? These are two different things. – oldchemist Apr 29 '17 at 18:05

As a partial answer to this broad question, one may provide a prediction about the partition of an organic compound between water and octanol, $\log p$. This often serves as one of the preliminary checks (prior to chemical synthesis) of compounds foreseen for a pharmaceutical application among the Lipinski rules. An example like this or this may provide a first experience; some molecular editors offer such an estimate, too.