Anybody has any idea how to do this? I tried converting the ketone to a alcohol using Grignard, but I have no idea how to proceed afterwards. I also tried starting with the Wittig reaction by converting to an alkene, but likewise, I dont know how to proceed. I have also tried working backwards, but to no avail as well. Anybody mind helping?
React the enolate of pinacolone (t-Bu Methyl ketone) with methyl vinyl ketone. It will first add 1,4 then the resulting enolate will do an aldol on the pinacolone ketone to give 3-tBu-cyclohexenone. React this with Phenyl cuprate and, despite the steric hindrance, it will add Michael-wise to give you the desired product.